Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia.

Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia.

To determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased and cytotoxicity decreased by encapsulation in poly(ɛ-caprolactone) nanocapsules (ATCnano), aiming at local or topical anesthesia in dentistry. Cellular viability was evaluated (using the MTT te...

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Bibliographic Details
Main Authors:	Camila Batista da Silva, Maria Cristina Volpato, Bruno Vilela Muniz, Cleiton Pita Dos Santos, Luciano Serpe, Luiz Eduardo Nunes Ferreira, Nathalie Ferreira Silva de Melo, Leonardo Fernandes Fraceto, Francisco Carlos Groppo, Michelle Franz-Montan
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2021-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0246760

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