The Endometrial Microbiome and Its Impact on Human Conception
Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/1/485 |
| _version_ | 1797498714659487744 |
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| author | Bruno Toson Carlos Simon Inmaculada Moreno |
| author_facet | Bruno Toson Carlos Simon Inmaculada Moreno |
| author_sort | Bruno Toson |
| collection | DOAJ |
| description | Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception. |
| first_indexed | 2024-03-10T03:37:18Z |
| format | Article |
| id | doaj.art-10f5c0adb7e549f3b968fc762cf95219 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:37:18Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-10f5c0adb7e549f3b968fc762cf952192023-11-23T11:40:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123148510.3390/ijms23010485The Endometrial Microbiome and Its Impact on Human ConceptionBruno Toson0Carlos Simon1Inmaculada Moreno2INCLIVA Biomedical Research Institute, Av. Menendez y Pelayo 4, 46010 Valencia, SpainIgenomix Foundation/INCLIVA Biomedical Research Institute, Narcis Monturiol Estarriol 11B, 46980 Paterna, SpainIgenomix Foundation/INCLIVA Biomedical Research Institute, Narcis Monturiol Estarriol 11B, 46980 Paterna, SpainChanges in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.https://www.mdpi.com/1422-0067/23/1/485endometrial microbiotamicrobiomereproductive tract microbiotauterusreproductive outcomesinfertility |
| spellingShingle | Bruno Toson Carlos Simon Inmaculada Moreno The Endometrial Microbiome and Its Impact on Human Conception International Journal of Molecular Sciences endometrial microbiota microbiome reproductive tract microbiota uterus reproductive outcomes infertility |
| title | The Endometrial Microbiome and Its Impact on Human Conception |
| title_full | The Endometrial Microbiome and Its Impact on Human Conception |
| title_fullStr | The Endometrial Microbiome and Its Impact on Human Conception |
| title_full_unstemmed | The Endometrial Microbiome and Its Impact on Human Conception |
| title_short | The Endometrial Microbiome and Its Impact on Human Conception |
| title_sort | endometrial microbiome and its impact on human conception |
| topic | endometrial microbiota microbiome reproductive tract microbiota uterus reproductive outcomes infertility |
| url | https://www.mdpi.com/1422-0067/23/1/485 |
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