Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice
Several religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course. This debate became more challenging after the publication of experimental studies su...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-06-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/674 |
| _version_ | 1818936169759506432 |
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| author | Soodeh Razeghi Jahromi Amir Ghaemi Akram Alizadeh Fatemeh Sabetghadam Hedieh Moradi Tabriz Mansoureh Togha |
| author_facet | Soodeh Razeghi Jahromi Amir Ghaemi Akram Alizadeh Fatemeh Sabetghadam Hedieh Moradi Tabriz Mansoureh Togha |
| author_sort | Soodeh Razeghi Jahromi |
| collection | DOAJ |
| description | Several religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course. This debate became more challenging after the publication of experimental studies suggesting that calorie restriction prior to disease induction attenuates disease severity. We conducted this study to assess early and late effects of fasting on the animal model of MS, known as autoimmune encephalomyelitis. EAE was induced in the C57BL/6 mice, using Myelin Oligodendrocyte Glycopeptide (MOG) 35-55 and they fasted every other day either after the appearance of the first clinical sign or 30 days after disease induction for ten days. Thereafter, the mice were sacrificed for further histological and immunological evaluations. Intermittent fasting after the establishment of EAE did not have any unfavorable effect on the course of disease. Moreover, fasting at the early phase of disease alleviated EAE severity by ameliorating spinal cord demyelination. Fasting suppressed the secretion of IFN-γ, TNF-α and raised IL-10 production in splenocytes. Fasting was also associated with a lower percent of cytotoxicity. Intermittent fasting not only had no unfavorable effect on EAE but also reduced EAE severity if started at early phase of disease. |
| first_indexed | 2024-12-20T05:31:48Z |
| format | Article |
| id | doaj.art-10f606611e394285a430772c7eb4ffb9 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-20T05:31:48Z |
| publishDate | 2016-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-10f606611e394285a430772c7eb4ffb92022-12-21T19:51:42ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492016-06-01153607Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 MiceSoodeh Razeghi Jahromi0Amir Ghaemi1Akram Alizadeh2Fatemeh Sabetghadam3Hedieh Moradi Tabriz4Mansoureh Togha5MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Shefa Neuroscience Research Centre, Khatam-Alanbia Hospital, Tehran, IranDepartment of Virology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran AND Shefa Neuroscience Research Centre, Khatam-Alanbia Hospital, Tehran, IranCellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranSchool of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, IranDepartment of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, IranHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranSeveral religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course. This debate became more challenging after the publication of experimental studies suggesting that calorie restriction prior to disease induction attenuates disease severity. We conducted this study to assess early and late effects of fasting on the animal model of MS, known as autoimmune encephalomyelitis. EAE was induced in the C57BL/6 mice, using Myelin Oligodendrocyte Glycopeptide (MOG) 35-55 and they fasted every other day either after the appearance of the first clinical sign or 30 days after disease induction for ten days. Thereafter, the mice were sacrificed for further histological and immunological evaluations. Intermittent fasting after the establishment of EAE did not have any unfavorable effect on the course of disease. Moreover, fasting at the early phase of disease alleviated EAE severity by ameliorating spinal cord demyelination. Fasting suppressed the secretion of IFN-γ, TNF-α and raised IL-10 production in splenocytes. Fasting was also associated with a lower percent of cytotoxicity. Intermittent fasting not only had no unfavorable effect on EAE but also reduced EAE severity if started at early phase of disease.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/674Calorie restrictionExperimental autoimmune encephalomyelitisFastingImmunityInflammationMultiple sclerosis |
| spellingShingle | Soodeh Razeghi Jahromi Amir Ghaemi Akram Alizadeh Fatemeh Sabetghadam Hedieh Moradi Tabriz Mansoureh Togha Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice Iranian Journal of Allergy, Asthma and Immunology Calorie restriction Experimental autoimmune encephalomyelitis Fasting Immunity Inflammation Multiple sclerosis |
| title | Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice |
| title_full | Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice |
| title_fullStr | Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice |
| title_full_unstemmed | Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice |
| title_short | Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice |
| title_sort | effects of intermittent fasting on experimental autoimune encephalomyelitis in c57bl 6 mice |
| topic | Calorie restriction Experimental autoimmune encephalomyelitis Fasting Immunity Inflammation Multiple sclerosis |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/674 |
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