Role of TLR4 in Persistent Leptospira interrogans Infection: A Comparative In Vivo Study in Mice

Role of TLR4 in Persistent Leptospira interrogans Infection: A Comparative In Vivo Study in Mice

Toll-Like Receptor (TLR) 4, the LPS receptor, plays a central role in the control of leptospirosis and absence of TLR4 results in lethal infection in mice. Because human TLR4 does not sense the atypical leptospiral-LPS, we hypothesized that TLR4/MD-2 humanized transgenic mice (huTLR4) may be more su...

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Bibliographic Details
Main Authors: Nisha Nair, Mariana S. Guedes, Adeline M. Hajjar, Catherine Werts, Maria Gomes-Solecki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Leptospira
leptospirosis
humanized TLR4/MD-2 mouse model
innate immunity
kidney
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.572999/full

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