Reverse transcriptase inhibition: a way to defeat HIV
Human immunodeficiency virus (HIV) induces disease in humans that is known as AIDS (acquired immunodeficiency syndrome). First AIDS cases were registered in 1981, and later, types of HIV infection, such as HIV-1 and HIV-2 were identified. HIV belongs to class of retroviruses, known as ‘lentiviruses...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2022-01-01
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| Series: | HIV & AIDS Review. International Journal of HIV-Related Problems |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Reverse-transcriptase-inhibition-a-way-to-defeat-HIV,106,46206,1,1.html |
| _version_ | 1817997078554476544 |
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| author | Vikas Kumar Harish Joshi I. Pandey |
| author_facet | Vikas Kumar Harish Joshi I. Pandey |
| author_sort | Vikas Kumar |
| collection | DOAJ |
| description | Human immunodeficiency virus (HIV) induces disease in humans that is known as AIDS (acquired immunodeficiency syndrome). First AIDS cases were registered in 1981, and later, types of HIV infection, such as HIV-1 and HIV-2 were identified. HIV belongs to class of retroviruses, known as ‘lentiviruses’ and ‘slow’ viruses. A literature assessment was conducted through several reliable national and international journals as well as books and monographs, to investigate reverse transcriptase inhibitor (RI) from human immunodeficiency virus type 1 (HIV-1). Reverse transcriptase inhibitor limits the reverse transcriptase activity, which is considered the key enzyme of retroviral multiplication process, and eventually prevents infection and progression of retroviruses. In the current paper, more than twenty-five drugs were presented, which are used for management/treatment of AIDS. The aim of the present review was to summarize the latest update on reverse transcriptase inhibition. Lately, significant advancement has been observed on the growth of HIV-drugs targeting reverse transcriptase enzyme. There is a continuous increase in various compounds with anti-HIV activity and isolated from natural sources. The present review provided a selection of publications concerning the topic. Salient features of reverse transcriptase inhibitors (both NRTIs and NNRTI's) and possibility for development of new chemical entity were presented. |
| first_indexed | 2024-04-14T02:32:56Z |
| format | Article |
| id | doaj.art-10f7aa0fddf74aca8bf6ed5e022dc409 |
| institution | Directory Open Access Journal |
| issn | 1730-1270 1732-2707 |
| language | English |
| last_indexed | 2024-04-14T02:32:56Z |
| publishDate | 2022-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | HIV & AIDS Review. International Journal of HIV-Related Problems |
| spelling | doaj.art-10f7aa0fddf74aca8bf6ed5e022dc4092022-12-22T02:17:36ZengTermedia Publishing HouseHIV & AIDS Review. International Journal of HIV-Related Problems1730-12701732-27072022-01-012113910.5114/hivar.2022.11276246206Reverse transcriptase inhibition: a way to defeat HIVVikas KumarHarish JoshiI. PandeyHuman immunodeficiency virus (HIV) induces disease in humans that is known as AIDS (acquired immunodeficiency syndrome). First AIDS cases were registered in 1981, and later, types of HIV infection, such as HIV-1 and HIV-2 were identified. HIV belongs to class of retroviruses, known as ‘lentiviruses’ and ‘slow’ viruses. A literature assessment was conducted through several reliable national and international journals as well as books and monographs, to investigate reverse transcriptase inhibitor (RI) from human immunodeficiency virus type 1 (HIV-1). Reverse transcriptase inhibitor limits the reverse transcriptase activity, which is considered the key enzyme of retroviral multiplication process, and eventually prevents infection and progression of retroviruses. In the current paper, more than twenty-five drugs were presented, which are used for management/treatment of AIDS. The aim of the present review was to summarize the latest update on reverse transcriptase inhibition. Lately, significant advancement has been observed on the growth of HIV-drugs targeting reverse transcriptase enzyme. There is a continuous increase in various compounds with anti-HIV activity and isolated from natural sources. The present review provided a selection of publications concerning the topic. Salient features of reverse transcriptase inhibitors (both NRTIs and NNRTI's) and possibility for development of new chemical entity were presented.https://www.termedia.pl/Reverse-transcriptase-inhibition-a-way-to-defeat-HIV,106,46206,1,1.htmlhuman immunodeficiency virus (hiv) acquired immunodeficiency syndrome (aids) reverse transcriptase inhibitors (rtis) |
| spellingShingle | Vikas Kumar Harish Joshi I. Pandey Reverse transcriptase inhibition: a way to defeat HIV HIV & AIDS Review. International Journal of HIV-Related Problems human immunodeficiency virus (hiv) acquired immunodeficiency syndrome (aids) reverse transcriptase inhibitors (rtis) |
| title | Reverse transcriptase inhibition: a way to defeat HIV |
| title_full | Reverse transcriptase inhibition: a way to defeat HIV |
| title_fullStr | Reverse transcriptase inhibition: a way to defeat HIV |
| title_full_unstemmed | Reverse transcriptase inhibition: a way to defeat HIV |
| title_short | Reverse transcriptase inhibition: a way to defeat HIV |
| title_sort | reverse transcriptase inhibition a way to defeat hiv |
| topic | human immunodeficiency virus (hiv) acquired immunodeficiency syndrome (aids) reverse transcriptase inhibitors (rtis) |
| url | https://www.termedia.pl/Reverse-transcriptase-inhibition-a-way-to-defeat-HIV,106,46206,1,1.html |
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