Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects
Abstract Plasmacytoid (PUC) variant is a rare and aggressive form of urothelial cancer representing 1 to 3% of the bladder cancer. The main differential diagnosis is the bladder involvement by lymphoma-plasmocytoma or metastasis from lobular breast cancer or diffuse gastric cancer. Immunexpression o...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Surgical and Experimental Pathology |
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| Online Access: | https://doi.org/10.1186/s42047-020-0056-5 |
| _version_ | 1818721511148617728 |
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| author | Katia Ramos Moreira Leite |
| author_facet | Katia Ramos Moreira Leite |
| author_sort | Katia Ramos Moreira Leite |
| collection | DOAJ |
| description | Abstract Plasmacytoid (PUC) variant is a rare and aggressive form of urothelial cancer representing 1 to 3% of the bladder cancer. The main differential diagnosis is the bladder involvement by lymphoma-plasmocytoma or metastasis from lobular breast cancer or diffuse gastric cancer. Immunexpression of cytokeratin 7 and GATA3 is the rule, but CD138 may be positive in high percentage of cases. CDH1 somatic mutation or, more rarely, methylation of the gene promoter is the main genetic characteristic of PUC, but germinative mutation is always negative. The recognition of this special histology is very important for the correct management of the patients because of the high rate of positive surgical margins and atypical disease progression. PUC is responsive to cisplatin-based chemotherapy but recurrence is the rule. Peritoneal dissemination is frequent and cancer specific mortality is as high as 56% in a range of 19 to 23 months. |
| first_indexed | 2024-12-17T20:39:53Z |
| format | Article |
| id | doaj.art-10fb99a1dba14fbb99edcba54d9c776e |
| institution | Directory Open Access Journal |
| issn | 2520-8454 |
| language | English |
| last_indexed | 2024-12-17T20:39:53Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Surgical and Experimental Pathology |
| spelling | doaj.art-10fb99a1dba14fbb99edcba54d9c776e2022-12-21T21:33:21ZengBMCSurgical and Experimental Pathology2520-84542020-01-01311510.1186/s42047-020-0056-5Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspectsKatia Ramos Moreira Leite0Laboratory of Medical Investigation – LIM55, Urology Department, University of Sao Paulo Medical SchoolAbstract Plasmacytoid (PUC) variant is a rare and aggressive form of urothelial cancer representing 1 to 3% of the bladder cancer. The main differential diagnosis is the bladder involvement by lymphoma-plasmocytoma or metastasis from lobular breast cancer or diffuse gastric cancer. Immunexpression of cytokeratin 7 and GATA3 is the rule, but CD138 may be positive in high percentage of cases. CDH1 somatic mutation or, more rarely, methylation of the gene promoter is the main genetic characteristic of PUC, but germinative mutation is always negative. The recognition of this special histology is very important for the correct management of the patients because of the high rate of positive surgical margins and atypical disease progression. PUC is responsive to cisplatin-based chemotherapy but recurrence is the rule. Peritoneal dissemination is frequent and cancer specific mortality is as high as 56% in a range of 19 to 23 months.https://doi.org/10.1186/s42047-020-0056-5Urinary bladderPlasmacytoidUrothelial carcinomaBladderVariantImmunohistochemistry |
| spellingShingle | Katia Ramos Moreira Leite Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects Surgical and Experimental Pathology Urinary bladder Plasmacytoid Urothelial carcinoma Bladder Variant Immunohistochemistry |
| title | Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects |
| title_full | Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects |
| title_fullStr | Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects |
| title_full_unstemmed | Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects |
| title_short | Plasmocytoid urothelial carcinoma - clinical, histological, immunohistochemical and molecular aspects |
| title_sort | plasmocytoid urothelial carcinoma clinical histological immunohistochemical and molecular aspects |
| topic | Urinary bladder Plasmacytoid Urothelial carcinoma Bladder Variant Immunohistochemistry |
| url | https://doi.org/10.1186/s42047-020-0056-5 |
| work_keys_str_mv | AT katiaramosmoreiraleite plasmocytoidurothelialcarcinomaclinicalhistologicalimmunohistochemicalandmolecularaspects |