Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

IntroductionGlioblastoma is a malignant brain tumor with poor prognosis. Lactate is the main product of tumor cells, and its secretion may relate to immunocytes’ activation. However, its role in glioblastoma is poorly understood. MethodsThis work performed bulk RNA-seq analysis and single cell RNA-s...

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Hlavní autoři: Zeyu Wang, Ziyu Dai, Hao Zhang, Xisong Liang, Xun Zhang, Zhipeng Wen, Peng Luo, Jian Zhang, Zaoqu Liu, Mingyu Zhang, Quan Cheng
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2023-04-01
Edice:Frontiers in Immunology
Témata:
glioblastoma
CD8+ T cells
interferon-gamma
immunocytes
chemotherapy
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2023.894853/full

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