Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

IntroductionGlioblastoma is a malignant brain tumor with poor prognosis. Lactate is the main product of tumor cells, and its secretion may relate to immunocytes’ activation. However, its role in glioblastoma is poorly understood. MethodsThis work performed bulk RNA-seq analysis and single cell RNA-s...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Zeyu Wang, Ziyu Dai, Hao Zhang, Xisong Liang, Xun Zhang, Zhipeng Wen, Peng Luo, Jian Zhang, Zaoqu Liu, Mingyu Zhang, Quan Cheng
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	Frontiers Media S.A. 2023-04-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	glioblastoma CD8+ T cells interferon-gamma immunocytes chemotherapy
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.894853/full

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