Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

IntroductionGlioblastoma is a malignant brain tumor with poor prognosis. Lactate is the main product of tumor cells, and its secretion may relate to immunocytes’ activation. However, its role in glioblastoma is poorly understood. MethodsThis work performed bulk RNA-seq analysis and single cell RNA-s...

Bibliografske podrobnosti
Main Authors:	Zeyu Wang, Ziyu Dai, Hao Zhang, Xisong Liang, Xun Zhang, Zhipeng Wen, Peng Luo, Jian Zhang, Zaoqu Liu, Mingyu Zhang, Quan Cheng
Format:	Article
Jezik:	English
Izdano:	Frontiers Media S.A. 2023-04-01
Serija:	Frontiers in Immunology
Teme:	glioblastoma CD8+ T cells interferon-gamma immunocytes chemotherapy
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.894853/full

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