Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

IntroductionGlioblastoma is a malignant brain tumor with poor prognosis. Lactate is the main product of tumor cells, and its secretion may relate to immunocytes’ activation. However, its role in glioblastoma is poorly understood. MethodsThis work performed bulk RNA-seq analysis and single cell RNA-s...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Zeyu Wang, Ziyu Dai, Hao Zhang, Xisong Liang, Xun Zhang, Zhipeng Wen, Peng Luo, Jian Zhang, Zaoqu Liu, Mingyu Zhang, Quan Cheng
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	Frontiers Media S.A. 2023-04-01
Loạt:	Frontiers in Immunology
Những chủ đề:	glioblastoma CD8+ T cells interferon-gamma immunocytes chemotherapy
Truy cập trực tuyến:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.894853/full

Những quyển sách tương tự

Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy
Bằng: Zeyu Wang, et al.
Được phát hành: (2020-08-01)

JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA Damage Repair to Facilitate Stemness Maintenance, Chemoresistance, and Immunosuppression in Pan-Cancer
Bằng: Xisong Liang, et al.
Được phát hành: (2022-07-01)

Identification of a Hypoxia-Angiogenesis lncRNA Signature Participating in Immunosuppression in Gastric Cancer
Bằng: Zicheng Wang, et al.
Được phát hành: (2022-01-01)

Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma
Bằng: Hao Zhang, et al.
Được phát hành: (2022-09-01)

CMTM Family Genes Affect Prognosis and Modulate Immunocytes Infiltration in Grade II/III Glioma Patients by Influencing the Tumor Immune Landscape and Activating Associated Immunosuppressing Pathways
Bằng: Zeyu Wang, et al.
Được phát hành: (2022-02-01)

Immunogenic cell death related risk model to delineate ferroptosis pathway and predict immunotherapy response of patients with GBM
Bằng: Songshan Feng, et al.
Được phát hành: (2022-09-01)

Integrated Analysis of Immune Infiltration Features for Cervical Carcinoma and Their Associated Immunotherapeutic Responses
Bằng: Yanan Kang, et al.
Được phát hành: (2021-04-01)

Research progress of immune checkpoint inhibitors in the treatment of glioblastoma
Bằng: JIA Xiaorong, et al.
Được phát hành: (2024-05-01)

Hyaluronic acids mediate the infiltration, migration, and M2 polarization of macrophages: evaluating metabolic molecular phenotypes in gliomas
Bằng: Hao Zhang, et al.
Được phát hành: (2022-12-01)

Pyroptosis-related prognosis model, immunocyte infiltration characterization, and competing endogenous RNA network of glioblastoma
Bằng: Min-Rui Ding, et al.
Được phát hành: (2022-06-01)

The Comprehensive Analysis Identified an Autophagy Signature for the Prognosis and the Immunotherapy Efficiency Prediction in Lung Adenocarcinoma
Bằng: Xizhe Li, et al.
Được phát hành: (2022-04-01)

Immune Infiltrating Cells-Derived Risk Signature Based on Large-scale Analysis Defines Immune Landscape and Predicts Immunotherapy Responses in Glioma Tumor Microenvironment
Bằng: Nan Zhang, et al.
Được phát hành: (2021-08-01)

Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy
Bằng: Yu Chen, et al.
Được phát hành: (2022-08-01)

Novel Immune Infiltrating Cell Signature Based on Cell Pair Algorithm Is a Prognostic Marker in Cancer
Bằng: Hao Zhang, et al.
Được phát hành: (2021-09-01)

TNFSF13 Is a Novel Onco-Inflammatory Marker and Correlates With Immune Infiltration in Gliomas
Bằng: Rui Chen, et al.
Được phát hành: (2021-10-01)

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression
Bằng: Zeyu Wang, et al.
Được phát hành: (2020-08-01)

The CXCL Family Contributes to Immunosuppressive Microenvironment in Gliomas and Assists in Gliomas Chemotherapy
Bằng: Zeyu Wang, et al.
Được phát hành: (2021-09-01)

Machine learning-based identification of SOX10 as an immune regulator of macrophage in gliomas
Bằng: Gelei Xiao, et al.
Được phát hành: (2022-11-01)

Identify the Prognostic and Immune Profile of VSIR in the Tumor Microenvironment: A Pan-Cancer Analysis
Bằng: Yuanyuan Liu, et al.
Được phát hành: (2022-04-01)

Corrigendum: Antigen Presentation Machinery Signature-Derived CALR Mediates Migration, Polarization of Macrophages in Glioma and Predicts Immunotherapy Response
Bằng: Rui Chen, et al.
Được phát hành: (2022-06-01)

Antigen Presentation Machinery Signature-Derived CALR Mediates Migration, Polarization of Macrophages in Glioma and Predicts Immunotherapy Response
Bằng: Rui Chen, et al.
Được phát hành: (2022-03-01)

Correlation Between APOBEC3B Expression and Clinical Characterization in Lower-Grade Gliomas
Bằng: Hao Zhang, et al.
Được phát hành: (2021-03-01)

Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas
Bằng: Hao Zhang, et al.
Được phát hành: (2020-08-01)

Correction to: Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas
Bằng: Hao Zhang, et al.
Được phát hành: (2020-09-01)

Large-Scale Single-Cell and Bulk Sequencing Analyses Reveal the Prognostic Value and Immune Aspects of CD147 in Pan-Cancer
Bằng: Jingwei Zhang, et al.
Được phát hành: (2022-04-01)

TP53 Mutation Infers a Poor Prognosis and Is Correlated to Immunocytes Infiltration in Breast Cancer
Bằng: Ziwen Zhang, et al.
Được phát hành: (2021-11-01)

The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma
Bằng: Wantao Wu, et al.
Được phát hành: (2024-01-01)

The adaptive transition of glioblastoma stem cells and its implications on treatments
Bằng: Zeyu Wang, et al.
Được phát hành: (2021-03-01)

Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer
Bằng: Hao Yang, et al.
Được phát hành: (2023-03-01)

Assessing the causal association between 731 immunophenotypes and the risk of colorectal cancer: a Mendelian randomization study
Bằng: Fei Gao, et al.
Được phát hành: (2025-02-01)

CTLA4-Mediated Immunosuppression in Glioblastoma is Associated with the Infiltration of Macrophages in the Tumor Microenvironment
Bằng: Guan X, et al.
Được phát hành: (2021-12-01)

Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
Bằng: Chonghua Jiang, et al.
Được phát hành: (2022-02-01)

Identification of Methylation Immune Subtypes and Establishment of a Prognostic Signature for Gliomas Using Immune-Related Genes
Bằng: Zhengang Hu, et al.
Được phát hành: (2021-11-01)

RUNX1/CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas: A single-cell sequencing analysis
Bằng: Hao Zhang, et al.
Được phát hành: (2023-01-01)

Prognostic Factors and Treatment Strategies for Elderly Patients with Malignant Meningioma: A SEER Population-Based Study
Bằng: Songshan Feng, et al.
Được phát hành: (2022-05-01)

The Predictive Value of Monocytes in Immune Microenvironment and Prognosis of Glioma Patients Based on Machine Learning
Bằng: Nan Zhang, et al.
Được phát hành: (2021-04-01)

Comprehensive analysis of lactate-related gene profiles and immune characteristics in lupus nephritis
Bằng: Zhan Sun, et al.
Được phát hành: (2024-02-01)

The role of lipocalin 2 in brain injury and recovery after ischemic and hemorrhagic stroke
Bằng: Jingwei Zhang, et al.
Được phát hành: (2022-09-01)

Artificial intelligence learning landscape of triple-negative breast cancer uncovers new opportunities for enhancing outcomes and immunotherapy responses
Bằng: Shuyu Li, et al.
Được phát hành: (2023-08-01)

Analysis of Immune-Related Signatures Related to CD4+ T Cell Infiltration With Gene Co-Expression Network in Pancreatic Adenocarcinoma
Bằng: Zhen Tan, et al.
Được phát hành: (2021-07-01)