A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
Abstract More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly ex...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23598-8 |
| _version_ | 1797984655306129408 |
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| author | Ruiqi Li Shuchong Mei Qiang Ding Qingming Wang Li Yu Fuming Zi |
| author_facet | Ruiqi Li Shuchong Mei Qiang Ding Qingming Wang Li Yu Fuming Zi |
| author_sort | Ruiqi Li |
| collection | DOAJ |
| description | Abstract More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression was associated with the infiltration of T follicular helper cells for the TCGA tumors of uveal melanoma, breast invasive carcinoma (BRCA), breast invasive carcinoma-luminalA (BRCA-LumA), head and neck squamous cell carcinoma (HNSC), head and neck squamous cell carcinoma with HPV positive (HNSC-HPV+), and cancer-associated fibroblasts for the tumors of brain lower grade glioma and stomach adenocarcinoma. Our first pan-cancer study offers a relatively comprehensive understanding of the roles of HK2 in different tumors. |
| first_indexed | 2024-04-11T07:06:24Z |
| format | Article |
| id | doaj.art-10ff7334c33f4b5e91a69d76c4b972ad |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T07:06:24Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-10ff7334c33f4b5e91a69d76c4b972ad2022-12-22T04:38:23ZengNature PortfolioScientific Reports2045-23222022-11-0112111110.1038/s41598-022-23598-8A pan-cancer analysis of the role of hexokinase II (HK2) in human tumorsRuiqi Li0Shuchong Mei1Qiang Ding2Qingming Wang3Li Yu4Fuming Zi5Department of Hematology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Hematology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Hematology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Hematology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Hematology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Hematology, The Second Affiliated Hospital of Nanchang UniversityAbstract More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression was associated with the infiltration of T follicular helper cells for the TCGA tumors of uveal melanoma, breast invasive carcinoma (BRCA), breast invasive carcinoma-luminalA (BRCA-LumA), head and neck squamous cell carcinoma (HNSC), head and neck squamous cell carcinoma with HPV positive (HNSC-HPV+), and cancer-associated fibroblasts for the tumors of brain lower grade glioma and stomach adenocarcinoma. Our first pan-cancer study offers a relatively comprehensive understanding of the roles of HK2 in different tumors.https://doi.org/10.1038/s41598-022-23598-8 |
| spellingShingle | Ruiqi Li Shuchong Mei Qiang Ding Qingming Wang Li Yu Fuming Zi A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors Scientific Reports |
| title | A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors |
| title_full | A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors |
| title_fullStr | A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors |
| title_full_unstemmed | A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors |
| title_short | A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors |
| title_sort | pan cancer analysis of the role of hexokinase ii hk2 in human tumors |
| url | https://doi.org/10.1038/s41598-022-23598-8 |
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