Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite cells or MuSCs); however, the relationship between...

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Bibliographic Details
Main Authors: Jacqueline A Larouche, Mahir Mohiuddin, Jeongmoon J Choi, Peter J Ulintz, Paula Fraczek, Kaitlyn Sabin, Sethuramasundaram Pitchiaya, Sarah J Kurpiers, Jesus Castor-Macias, Wenxuan Liu, Robert Louis Hastings, Lemuel A Brown, James F Markworth, Kanishka De Silva, Benjamin Levi, Sofia D Merajver, Gregorio Valdez, Joe V Chakkalakal, Young C Jang, Susan V Brooks, Carlos A Aguilar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
single cell RNA-seq
aging
neuromuscular junction
synapse
Online Access:https://elifesciences.org/articles/66749

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