Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory Activities
In the current study, further chemical investigation of the fruiting bodies of <i>Fomes officinalis</i> led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I−O (<b>1</b>–<b>7</b>). Their structures were elucidated based on the ana...
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/20/4807 |
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| author | Jianxin Han Wei Liu Miaomiao Li Yanpei Gu Ying Zhang Tao Yuan |
| author_facet | Jianxin Han Wei Liu Miaomiao Li Yanpei Gu Ying Zhang Tao Yuan |
| author_sort | Jianxin Han |
| collection | DOAJ |
| description | In the current study, further chemical investigation of the fruiting bodies of <i>Fomes officinalis</i> led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I−O (<b>1</b>–<b>7</b>). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR). Compounds <b>1</b>−<b>3</b> possessed an unusual C-23 spirostructure moiety, while compounds <b>4</b>−<b>7</b> had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds <b>3</b> and <b>5</b> exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2). |
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| id | doaj.art-11049dd2b8714bacbb1baa780546d40b |
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| language | English |
| last_indexed | 2024-03-10T15:30:13Z |
| publishDate | 2020-10-01 |
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| series | Molecules |
| spelling | doaj.art-11049dd2b8714bacbb1baa780546d40b2023-11-20T17:42:58ZengMDPI AGMolecules1420-30492020-10-012520480710.3390/molecules25204807Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory ActivitiesJianxin Han0Wei Liu1Miaomiao Li2Yanpei Gu3Ying Zhang4Tao Yuan5Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, ChinaThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, ChinaThe Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, ChinaDepartment of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, ChinaThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, ChinaIn the current study, further chemical investigation of the fruiting bodies of <i>Fomes officinalis</i> led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I−O (<b>1</b>–<b>7</b>). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR). Compounds <b>1</b>−<b>3</b> possessed an unusual C-23 spirostructure moiety, while compounds <b>4</b>−<b>7</b> had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds <b>3</b> and <b>5</b> exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2).https://www.mdpi.com/1420-3049/25/20/4807<i>Fomes officinalis</i>polyporaceaelanostane triterpenoidspirostructureanti-inflammatory |
| spellingShingle | Jianxin Han Wei Liu Miaomiao Li Yanpei Gu Ying Zhang Tao Yuan Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory Activities Molecules <i>Fomes officinalis</i> polyporaceae lanostane triterpenoid spirostructure anti-inflammatory |
| title | Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory Activities |
| title_full | Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory Activities |
| title_fullStr | Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory Activities |
| title_full_unstemmed | Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory Activities |
| title_short | Lanostane Triterpenoids from the Fruiting Bodies of <i>Fomes officinalis</i> and Their Anti-Inflammatory Activities |
| title_sort | lanostane triterpenoids from the fruiting bodies of i fomes officinalis i and their anti inflammatory activities |
| topic | <i>Fomes officinalis</i> polyporaceae lanostane triterpenoid spirostructure anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/25/20/4807 |
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