Roquin-1 resolves sepsis-associated acute liver injury by regulating inflammatory profiles via miRNA cargo in extracellular vesicles

Roquin-1 resolves sepsis-associated acute liver injury by regulating inflammatory profiles via miRNA cargo in extracellular vesicles

Summary: Sepsis-associated acute liver injury (SALI) is an independent risk for sepsis-induced death orchestrated by innate and adaptive immune responses. Here, we found that Roquin-1 was decreased during SALI and expressed mainly in monocyte-derived macrophages. Meanwhile, Roquin-1 was correlated w...

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Bibliographic Details
Main Authors: Lei Zheng, Wei Ling, Deming Zhu, Zhi Li, Yousheng Li, Haoming Zhou, Lianbao Kong
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Pathophysiology
Molecular biology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422301372X

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