Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor Therapy
The use of TNF-alpha inhibitor agents facilitates mycobacterial infections. Unlike in normal population, active tuberculosis in such patients may be asymptomatic. Here we present the case of an asymptomatic child who developed pulmonary tuberculosis during TNF-alpha inhibitor therapy. A 12-year-old...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2017-03-01
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| Series: | İstanbul Medical Journal |
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| Online Access: |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/asymptomatic-pulmonary-tuberculosis-in-a-child-und/20430
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| _version_ | 1797907409661853696 |
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| author | Manolya Acar Fatih Karagözlü Murat Sütçü Oğuz Bülent Erol Selda Hancerli Torun Nuran Salman Ayper Somer |
| author_facet | Manolya Acar Fatih Karagözlü Murat Sütçü Oğuz Bülent Erol Selda Hancerli Torun Nuran Salman Ayper Somer |
| author_sort | Manolya Acar |
| collection | DOAJ |
| description | The use of TNF-alpha inhibitor agents facilitates mycobacterial infections. Unlike in normal population, active tuberculosis in such patients may be asymptomatic. Here we present the case of an asymptomatic child who developed pulmonary tuberculosis during TNF-alpha inhibitor therapy. A 12-year-old child with a diagnosis of juvenile idiopathic arthritis and uveitis was referred to our clinic before initiation of adalimumab therapy. His tuberculin skin test was negative and chest X-ray was normal prior to therapy. On the third month of his therapy, his father was diagnosed with pulmonary tuberculosis, and he was initiated on isoniazid therapy. A month later, the patient’s tuberculin skin test was measured as 7 mm, and chest X-ray revealed paratracheal opacity. Computerized tomographic scan confirmed a necrotic mass lesion with a size of 40x27x24 mm which was compatible with tuberculosis. He was thus initiated on antituberculosis therapy. Patients undergoing anti TNF-alpha therapy should be followed up for tuberculosis before and during therapy. |
| first_indexed | 2024-04-10T10:37:21Z |
| format | Article |
| id | doaj.art-110500094174499a9bd059d8bd2257aa |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T10:37:21Z |
| publishDate | 2017-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-110500094174499a9bd059d8bd2257aa2023-02-15T16:20:48ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2017-03-01181474910.5152/imj.2017.9705913049054Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor TherapyManolya Acar0Fatih Karagözlü1Murat Sütçü2Oğuz Bülent Erol3Selda Hancerli Torun4Nuran Salman5Ayper Somer6 Division of Pediatric Infection and Clinical Immunology, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye Division of Pediatric Infection and Clinical Immunology, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye Division of Pediatric Infection and Clinical Immunology, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye Department of Radiology, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye Division of Pediatric Infection and Clinical Immunology, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye Division of Pediatric Infection and Clinical Immunology, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye Division of Pediatric Infection and Clinical Immunology, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye The use of TNF-alpha inhibitor agents facilitates mycobacterial infections. Unlike in normal population, active tuberculosis in such patients may be asymptomatic. Here we present the case of an asymptomatic child who developed pulmonary tuberculosis during TNF-alpha inhibitor therapy. A 12-year-old child with a diagnosis of juvenile idiopathic arthritis and uveitis was referred to our clinic before initiation of adalimumab therapy. His tuberculin skin test was negative and chest X-ray was normal prior to therapy. On the third month of his therapy, his father was diagnosed with pulmonary tuberculosis, and he was initiated on isoniazid therapy. A month later, the patient’s tuberculin skin test was measured as 7 mm, and chest X-ray revealed paratracheal opacity. Computerized tomographic scan confirmed a necrotic mass lesion with a size of 40x27x24 mm which was compatible with tuberculosis. He was thus initiated on antituberculosis therapy. Patients undergoing anti TNF-alpha therapy should be followed up for tuberculosis before and during therapy. http://imj.galenos.com.tr/archives/archive-detail/article-preview/asymptomatic-pulmonary-tuberculosis-in-a-child-und/20430 ChildTNF-alpha inhibitortuberculosis |
| spellingShingle | Manolya Acar Fatih Karagözlü Murat Sütçü Oğuz Bülent Erol Selda Hancerli Torun Nuran Salman Ayper Somer Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor Therapy İstanbul Medical Journal Child TNF-alpha inhibitor tuberculosis |
| title | Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor Therapy |
| title_full | Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor Therapy |
| title_fullStr | Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor Therapy |
| title_full_unstemmed | Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor Therapy |
| title_short | Asymptomatic Pulmonary Tuberculosis in a Child under TNF-alpha Inhibitor Therapy |
| title_sort | asymptomatic pulmonary tuberculosis in a child under tnf alpha inhibitor therapy |
| topic | Child TNF-alpha inhibitor tuberculosis |
| url |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/asymptomatic-pulmonary-tuberculosis-in-a-child-und/20430
|
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