Study of nanolayer on red blood cells as drug carrier in an artery with stenosis
This article discusses a novel idea from cell therapy in which nanoparticles (NPs) are adsorbed on red blood cells (RBCs). RBCs serve as a drug carrier for NPs or nanodrugs adsorbed on the cell membrane of RBC. For the purpose of examination, Fe3O4{{\rm{Fe}}}_{3}{{\rm{O}}}_{4} NPs are adsorbed on RB...
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-11-01
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| Series: | Computational and Mathematical Biophysics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cmb-2023-0103 |
| _version_ | 1827763331063087104 |
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| author | Prasad Bhawini |
| author_facet | Prasad Bhawini |
| author_sort | Prasad Bhawini |
| collection | DOAJ |
| description | This article discusses a novel idea from cell therapy in which nanoparticles (NPs) are adsorbed on red blood cells (RBCs). RBCs serve as a drug carrier for NPs or nanodrugs adsorbed on the cell membrane of RBC. For the purpose of examination, Fe3O4{{\rm{Fe}}}_{3}{{\rm{O}}}_{4} NPs are adsorbed on RBCs, collectively called NP-RBC complex. RBCs being a natural vascular carrier, have high transfusion rates and biocompatibility. This mathematical study provides a basis to attempt nanodrug delivery via RBCs, as carriers for nanodrugs, to the stenosed sites in an artery. The mathematical model is developed for an artery with stenosis and a catheter that regards the temperature and velocity of the NP-RBC complex. Catheter coated with the NP-RBC complex is inserted into the lumen of the stenosed artery. The mathematical problem is solved numerically using Bernstein polynomials. The physical features were discussed through graphs plotted using MATLAB. The influence of parameters such as volume fraction, radius of the NP-RBC complex in blood, and the thickness of the nanolayer on RBCs was studied. A noticeable outcome states that the nanolayer of optimum thickness about 50–40 nm is suitable for this purpose. Thus, this is an attempt to study the delivery of NPs adsorbed on the surface of RBCs to develop newfangled strategies in nanomedicine bearing high precision and efficiency. |
| first_indexed | 2024-03-11T10:50:38Z |
| format | Article |
| id | doaj.art-1108414f44da47cf9f29f36610b1e835 |
| institution | Directory Open Access Journal |
| issn | 2544-7297 |
| language | English |
| last_indexed | 2024-03-11T10:50:38Z |
| publishDate | 2023-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Computational and Mathematical Biophysics |
| spelling | doaj.art-1108414f44da47cf9f29f36610b1e8352023-11-13T18:27:41ZengDe GruyterComputational and Mathematical Biophysics2544-72972023-11-01111233522336810.1515/cmb-2023-0103Study of nanolayer on red blood cells as drug carrier in an artery with stenosisPrasad Bhawini0Department of Mathematics, Harcourt Butler Technical University, Kanpur, Uttar Pradesh 208002, IndiaThis article discusses a novel idea from cell therapy in which nanoparticles (NPs) are adsorbed on red blood cells (RBCs). RBCs serve as a drug carrier for NPs or nanodrugs adsorbed on the cell membrane of RBC. For the purpose of examination, Fe3O4{{\rm{Fe}}}_{3}{{\rm{O}}}_{4} NPs are adsorbed on RBCs, collectively called NP-RBC complex. RBCs being a natural vascular carrier, have high transfusion rates and biocompatibility. This mathematical study provides a basis to attempt nanodrug delivery via RBCs, as carriers for nanodrugs, to the stenosed sites in an artery. The mathematical model is developed for an artery with stenosis and a catheter that regards the temperature and velocity of the NP-RBC complex. Catheter coated with the NP-RBC complex is inserted into the lumen of the stenosed artery. The mathematical problem is solved numerically using Bernstein polynomials. The physical features were discussed through graphs plotted using MATLAB. The influence of parameters such as volume fraction, radius of the NP-RBC complex in blood, and the thickness of the nanolayer on RBCs was studied. A noticeable outcome states that the nanolayer of optimum thickness about 50–40 nm is suitable for this purpose. Thus, this is an attempt to study the delivery of NPs adsorbed on the surface of RBCs to develop newfangled strategies in nanomedicine bearing high precision and efficiency.https://doi.org/10.1515/cmb-2023-0103nanoparticlesnanolayerstenosisbernstein polynomials35q9292c4597m6035a2476d05 |
| spellingShingle | Prasad Bhawini Study of nanolayer on red blood cells as drug carrier in an artery with stenosis Computational and Mathematical Biophysics nanoparticles nanolayer stenosis bernstein polynomials 35q92 92c45 97m60 35a24 76d05 |
| title | Study of nanolayer on red blood cells as drug carrier in an artery with stenosis |
| title_full | Study of nanolayer on red blood cells as drug carrier in an artery with stenosis |
| title_fullStr | Study of nanolayer on red blood cells as drug carrier in an artery with stenosis |
| title_full_unstemmed | Study of nanolayer on red blood cells as drug carrier in an artery with stenosis |
| title_short | Study of nanolayer on red blood cells as drug carrier in an artery with stenosis |
| title_sort | study of nanolayer on red blood cells as drug carrier in an artery with stenosis |
| topic | nanoparticles nanolayer stenosis bernstein polynomials 35q92 92c45 97m60 35a24 76d05 |
| url | https://doi.org/10.1515/cmb-2023-0103 |
| work_keys_str_mv | AT prasadbhawini studyofnanolayeronredbloodcellsasdrugcarrierinanarterywithstenosis |