Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
Mihoko Kawamura, Yoshio Hirano, Munenori Yoshida, Takeshi Mizutani, Kazuhiko Sugitani, Tsutomu Yasukawa, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Purpose: The aim of this study is to report the 6-...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-08-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/six-month-results-of-intravitreal-ranibizumab-for-macular-edema-after--peer-reviewed-article-OPTH |
| _version_ | 1818433410260008960 |
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| author | Kawamura M Hirano Y Yoshida M Mizutani T Sugitani K Yasukawa T Ogura Y |
| author_facet | Kawamura M Hirano Y Yoshida M Mizutani T Sugitani K Yasukawa T Ogura Y |
| author_sort | Kawamura M |
| collection | DOAJ |
| description | Mihoko Kawamura, Yoshio Hirano, Munenori Yoshida, Takeshi Mizutani, Kazuhiko Sugitani, Tsutomu Yasukawa, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Purpose: The aim of this study is to report the 6-month results after one intravitreal ranibizumab (IVR) injection followed by pro re nata dosing for macular edema (ME) after branch retinal vein occlusion.Patients and methods: The inclusion criteria included a minimal patient age of 18 years, 20 letters or more best-corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study [ETDRS] score, 77 letters or less), and central retinal thickness (CRT) of 250 microns or more. The primary outcome measure was the mean BCVA change from baseline at month 6; the secondary outcomes were mean changes in CRT, residual ME, and microaneurysm formation.Results: Twenty patients were enrolled from March 2014 through October 2016 at Nagoya City University Hospital. The baseline mean ETDRS letters and CRT were 63.1 and 500 microns, respectively; mean time from symptom onset to initial therapy was 1.80 months; and mean ETDRS gain and CRT reduction were 15.2 letters and 230 microns, respectively. The percentages of patients with Snellen equivalent BCVAs of 20/40 (70 ETDRS letters) or better and 20/20 (85 ETDRS letters) were 90% and 15%, respectively. Residual ME and microaneurysms were observed in 85% and 35% of patients. Microaneurysm formation was associated with delayed initial therapy.Conclusion: Prompt initiation of IVR injection provided a better visual prognosis at month 6 and suppressed the microaneurysm formation. Keywords: branch retinal vein occlusion, macular edema, microaneurysm, ranibizumab, prompt treatment |
| first_indexed | 2024-12-14T16:20:39Z |
| format | Article |
| id | doaj.art-110964b6729440d2bf9e055bee5f4980 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-14T16:20:39Z |
| publishDate | 2018-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-110964b6729440d2bf9e055bee5f49802022-12-21T22:54:48ZengDove Medical PressClinical Ophthalmology1177-54832018-08-01Volume 121487149439950Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formationKawamura MHirano YYoshida MMizutani TSugitani KYasukawa TOgura YMihoko Kawamura, Yoshio Hirano, Munenori Yoshida, Takeshi Mizutani, Kazuhiko Sugitani, Tsutomu Yasukawa, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Purpose: The aim of this study is to report the 6-month results after one intravitreal ranibizumab (IVR) injection followed by pro re nata dosing for macular edema (ME) after branch retinal vein occlusion.Patients and methods: The inclusion criteria included a minimal patient age of 18 years, 20 letters or more best-corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study [ETDRS] score, 77 letters or less), and central retinal thickness (CRT) of 250 microns or more. The primary outcome measure was the mean BCVA change from baseline at month 6; the secondary outcomes were mean changes in CRT, residual ME, and microaneurysm formation.Results: Twenty patients were enrolled from March 2014 through October 2016 at Nagoya City University Hospital. The baseline mean ETDRS letters and CRT were 63.1 and 500 microns, respectively; mean time from symptom onset to initial therapy was 1.80 months; and mean ETDRS gain and CRT reduction were 15.2 letters and 230 microns, respectively. The percentages of patients with Snellen equivalent BCVAs of 20/40 (70 ETDRS letters) or better and 20/20 (85 ETDRS letters) were 90% and 15%, respectively. Residual ME and microaneurysms were observed in 85% and 35% of patients. Microaneurysm formation was associated with delayed initial therapy.Conclusion: Prompt initiation of IVR injection provided a better visual prognosis at month 6 and suppressed the microaneurysm formation. Keywords: branch retinal vein occlusion, macular edema, microaneurysm, ranibizumab, prompt treatmenthttps://www.dovepress.com/six-month-results-of-intravitreal-ranibizumab-for-macular-edema-after--peer-reviewed-article-OPTHbranch retinal vein occlusionmacular edemamicroaneurysmranibizumab |
| spellingShingle | Kawamura M Hirano Y Yoshida M Mizutani T Sugitani K Yasukawa T Ogura Y Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation Clinical Ophthalmology branch retinal vein occlusion macular edema microaneurysm ranibizumab |
| title | Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation |
| title_full | Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation |
| title_fullStr | Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation |
| title_full_unstemmed | Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation |
| title_short | Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation |
| title_sort | six month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single center prospective study visual outcomes and microaneurysm formation |
| topic | branch retinal vein occlusion macular edema microaneurysm ranibizumab |
| url | https://www.dovepress.com/six-month-results-of-intravitreal-ranibizumab-for-macular-edema-after--peer-reviewed-article-OPTH |
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