The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran
Background: Considering the controversial information regarding the effects of perchlorate on thyroid function of high risk population as neonates, and given the high prevalence rate of thyroid disorders specially congenital hypothyroidism in our region, this study aims to investigate for the first...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=17;epage=17;aulast=Javidi |
| _version_ | 1811307614822203392 |
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| author | Ashraf Javidi Nasim Rafiei Mohammad Mehdi Amin Silva Hovsepian Mahin Hashemipour Roya Kelishadi Zahra Taghian Samaneh Mofateh Parinaz Poursafa |
| author_facet | Ashraf Javidi Nasim Rafiei Mohammad Mehdi Amin Silva Hovsepian Mahin Hashemipour Roya Kelishadi Zahra Taghian Samaneh Mofateh Parinaz Poursafa |
| author_sort | Ashraf Javidi |
| collection | DOAJ |
| description | Background: Considering the controversial information regarding the effects of perchlorate on thyroid function of high risk population as neonates, and given the high prevalence rate of thyroid disorders specially congenital hypothyroidism in our region, this study aims to investigate for the first time in Iran, the relationship between drinking groundwater perchlorate and cord blood thyroid hormones level in an industrial region.
Methods: In this cross-sectional study, drinking groundwater perchlorate level of rural areas of Zarinshahr, Isfahan was measured. Simultaneously, cord blood level of thyroid hormones of neonates born in the studied region was measured. Thyroid function test of neonates in regions with low and high perchlorate level were compared.
Results: In this study, 25 tap water samples were obtained for perchlorate measurement. Level of cord blood thyroid stimulating hormone (TSH), T4 and T3 of 25 neonates were measured. Mean (standard deviation) of perchlorate, TSH, T4 and T3 was 3.59 (5.10) μg/l, 7.81 (4.14) mIU/m, 6.06 (0.85) mg/dl, and 63.46 (17.53) mg/dl, respectively. Mean levels of thyroid function tests were not different in low (<5 μg/l) and high level of drinking ground water perchlorate (P > 0.05).
Conclusions: Perchlorate did not appear to be related to thyroid function of neonates in the studied industrial region. It seems that iodine status of the regions, as well as other environmental contaminants and genetic background, could impact on its relation with thyroid function of neonates. |
| first_indexed | 2024-04-13T09:07:57Z |
| format | Article |
| id | doaj.art-1109b8d0c6c546daa5842362eef390ee |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-04-13T09:07:57Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-1109b8d0c6c546daa5842362eef390ee2022-12-22T02:52:57ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132015-01-0161171710.4103/2008-7802.151826The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from IranAshraf JavidiNasim RafieiMohammad Mehdi AminSilva HovsepianMahin HashemipourRoya KelishadiZahra TaghianSamaneh MofatehParinaz PoursafaBackground: Considering the controversial information regarding the effects of perchlorate on thyroid function of high risk population as neonates, and given the high prevalence rate of thyroid disorders specially congenital hypothyroidism in our region, this study aims to investigate for the first time in Iran, the relationship between drinking groundwater perchlorate and cord blood thyroid hormones level in an industrial region. Methods: In this cross-sectional study, drinking groundwater perchlorate level of rural areas of Zarinshahr, Isfahan was measured. Simultaneously, cord blood level of thyroid hormones of neonates born in the studied region was measured. Thyroid function test of neonates in regions with low and high perchlorate level were compared. Results: In this study, 25 tap water samples were obtained for perchlorate measurement. Level of cord blood thyroid stimulating hormone (TSH), T4 and T3 of 25 neonates were measured. Mean (standard deviation) of perchlorate, TSH, T4 and T3 was 3.59 (5.10) μg/l, 7.81 (4.14) mIU/m, 6.06 (0.85) mg/dl, and 63.46 (17.53) mg/dl, respectively. Mean levels of thyroid function tests were not different in low (<5 μg/l) and high level of drinking ground water perchlorate (P > 0.05). Conclusions: Perchlorate did not appear to be related to thyroid function of neonates in the studied industrial region. It seems that iodine status of the regions, as well as other environmental contaminants and genetic background, could impact on its relation with thyroid function of neonates.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=17;epage=17;aulast=JavidiEnvironmentinfantperchloratethyroid gland |
| spellingShingle | Ashraf Javidi Nasim Rafiei Mohammad Mehdi Amin Silva Hovsepian Mahin Hashemipour Roya Kelishadi Zahra Taghian Samaneh Mofateh Parinaz Poursafa The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran International Journal of Preventive Medicine Environment infant perchlorate thyroid gland |
| title | The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran |
| title_full | The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran |
| title_fullStr | The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran |
| title_full_unstemmed | The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran |
| title_short | The relationship between perchlorate in drinking water and cord blood thyroid hormones: First experience from Iran |
| title_sort | relationship between perchlorate in drinking water and cord blood thyroid hormones first experience from iran |
| topic | Environment infant perchlorate thyroid gland |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=17;epage=17;aulast=Javidi |
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