Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris
Suparat Wangsuwan, Jitlada Meephansan Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, ThailandCorrespondence: Jitlada MeephansanDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-11-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/comparative-study-of-photodynamic-therapy-with-riboflavin-tryptophan-g-peer-reviewed-article-CCID |
| _version_ | 1818284249301647360 |
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| author | Wangsuwan S Meephansan J |
| author_facet | Wangsuwan S Meephansan J |
| author_sort | Wangsuwan S |
| collection | DOAJ |
| description | Suparat Wangsuwan, Jitlada Meephansan Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, ThailandCorrespondence: Jitlada MeephansanDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani 12120, ThailandTel +66 02 564 4444 Ext 4495Email kae_mdcu@yahoo.comBackground: Non-invasive photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) has been used as an alternative acne treatment for many years. Riboflavin and tryptophan are newly introduced photosensitizers.Objective: To compare the efficacy of PDT with riboflavin-tryptophan (RT) gel with that of 13% ALA for the treatment of facial acne.Methods: We performed a double-blind, split-face study of 37 subjects with mild to moderate facial acne vulgaris. RT gel was applied to half of the face, and 13% ALA was applied to the other half. Then, the whole face was irradiated using a blue light-emitting diode for 20 mins. Four treatment sessions were performed over a 4-week duration, at 1-week interval. The acne lesion counts and acne severity were assessed. Sebum secretion, Propionibacterium acne colonization, pore size, and skin texture were also evaluated.Results: PDT with RT gel demonstrated good efficacy, non-inferior to ALA for acne treatment, with a significant reduction in acne lesion counts, severity grading, porphyrin, and sebum output. The pore size and skin texture were improved. Side-effects were minimal and well tolerated in all subjects.Conclusion: PDT therapy with RT gel is an effective alternative treatment for acne vulgaris.Keywords: acne vulgaris, photodynamic therapy, 5-aminolevulinic acid, riboflavin, tryptophan |
| first_indexed | 2024-12-13T00:49:48Z |
| format | Article |
| id | doaj.art-110d9db75d3d400a991bcb08619c8237 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-13T00:49:48Z |
| publishDate | 2019-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-110d9db75d3d400a991bcb08619c82372022-12-22T00:04:56ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152019-11-01Volume 1280581449531Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne VulgarisWangsuwan SMeephansan JSuparat Wangsuwan, Jitlada Meephansan Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, ThailandCorrespondence: Jitlada MeephansanDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani 12120, ThailandTel +66 02 564 4444 Ext 4495Email kae_mdcu@yahoo.comBackground: Non-invasive photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) has been used as an alternative acne treatment for many years. Riboflavin and tryptophan are newly introduced photosensitizers.Objective: To compare the efficacy of PDT with riboflavin-tryptophan (RT) gel with that of 13% ALA for the treatment of facial acne.Methods: We performed a double-blind, split-face study of 37 subjects with mild to moderate facial acne vulgaris. RT gel was applied to half of the face, and 13% ALA was applied to the other half. Then, the whole face was irradiated using a blue light-emitting diode for 20 mins. Four treatment sessions were performed over a 4-week duration, at 1-week interval. The acne lesion counts and acne severity were assessed. Sebum secretion, Propionibacterium acne colonization, pore size, and skin texture were also evaluated.Results: PDT with RT gel demonstrated good efficacy, non-inferior to ALA for acne treatment, with a significant reduction in acne lesion counts, severity grading, porphyrin, and sebum output. The pore size and skin texture were improved. Side-effects were minimal and well tolerated in all subjects.Conclusion: PDT therapy with RT gel is an effective alternative treatment for acne vulgaris.Keywords: acne vulgaris, photodynamic therapy, 5-aminolevulinic acid, riboflavin, tryptophanhttps://www.dovepress.com/comparative-study-of-photodynamic-therapy-with-riboflavin-tryptophan-g-peer-reviewed-article-CCIDacne vulgarisphotodynamic therapy5-aminolevulinic acidriboflavintryptophan |
| spellingShingle | Wangsuwan S Meephansan J Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris Clinical, Cosmetic and Investigational Dermatology acne vulgaris photodynamic therapy 5-aminolevulinic acid riboflavin tryptophan |
| title | Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris |
| title_full | Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris |
| title_fullStr | Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris |
| title_full_unstemmed | Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris |
| title_short | Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris |
| title_sort | comparative study of photodynamic therapy with riboflavin tryptophan gel and 13 5 aminolevulinic acid in the treatment of mild to moderate acne vulgaris |
| topic | acne vulgaris photodynamic therapy 5-aminolevulinic acid riboflavin tryptophan |
| url | https://www.dovepress.com/comparative-study-of-photodynamic-therapy-with-riboflavin-tryptophan-g-peer-reviewed-article-CCID |
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