The Influence of the Solid Solution Formation on Purification of <i>L</i>-Menthol from the Enantiomer Mixture by Three-Phase Crystallization
Three-phase crystallization (TPC) was introduced in this study to purify <i>L</i>-menthol from menthol enantiomer mixtures in consideration of the formation of solid solutions. TPC is a new separation technology, which combines melt crystallization and vaporization to result in the desir...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/19/14933 |
| Summary: | Three-phase crystallization (TPC) was introduced in this study to purify <i>L</i>-menthol from menthol enantiomer mixtures in consideration of the formation of solid solutions. TPC is a new separation technology, which combines melt crystallization and vaporization to result in the desired crystalline product from a liquid mixture along with the unwanted components vaporized via the three-phase transformation by reducing temperature and pressure. The three-phase transformation conditions for the liquid menthol enantiomer mixtures were determined based on the thermodynamic calculations to direct the TPC experiments. A new model was proposed based on the mass and energy balances in consideration of the formation of the solid solutions to predict the yield and purity of the final <i>L</i>-menthol product during TPC. The yield and purity obtained from the TPC experiments were compared with those predicted by the model. |
|---|---|
| ISSN: | 1661-6596 1422-0067 |