PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents
Abstract Background Pediatric community acquired pneumonia (pedCAP) is one of the leading causes for childhood morbidity accounting for up to 20% of pediatric hospital admissions in high income countries. In spite of its high morbidity, updated epidemiological and pathogen data after introduction of...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-12-01
|
| Series: | BMC Pulmonary Medicine |
| Online Access: | https://doi.org/10.1186/s12890-019-1013-5 |
| _version_ | 1831767685800656896 |
|---|---|
| author | Martin Wetzke Matthias Volkmar Kopp Jürgen Seidenberg Christian Vogelberg Tobias Ankermann Christine Happle Gesche Voigt Holger Köster Thomas Illig Christiane Lex Antje Schuster Marcus Panning Grit Barten Gernot Rohde Tobias Welte Gesine Hansen pedCAPNETZ Study Group |
| author_facet | Martin Wetzke Matthias Volkmar Kopp Jürgen Seidenberg Christian Vogelberg Tobias Ankermann Christine Happle Gesche Voigt Holger Köster Thomas Illig Christiane Lex Antje Schuster Marcus Panning Grit Barten Gernot Rohde Tobias Welte Gesine Hansen pedCAPNETZ Study Group |
| author_sort | Martin Wetzke |
| collection | DOAJ |
| description | Abstract Background Pediatric community acquired pneumonia (pedCAP) is one of the leading causes for childhood morbidity accounting for up to 20% of pediatric hospital admissions in high income countries. In spite of its high morbidity, updated epidemiological and pathogen data after introduction of preventive vaccination and novel pathogen screening strategies are limited. Moreover, there is a need for validated recommendations on diagnostic and treatment regimens in pedCAP. Through collection of patient data and analysis of pathogen and host factors in a large sample of unselected pedCAP patients in Germany, we aim to address and substantially improve this situation. Methods pedCAPNETZ is an observational, multi-center study on pedCAP. Thus far, nine study centers in hospitals, outpatient clinics and practices have been initiated and more than 400 patients with radiologically confirmed pneumonia have been enrolled, aiming at a total of 1000 study participants. Employing an online data base, information on disease course, treatment as well as demographical and socioeconomical data is recorded. Patients are followed up until day 90 after enrollment; Comprehensive biosample collection and a central pedCAPNETZ biobank allow for in-depth analyses of pathogen and host factors. Standardized workflows to assure sample logistics and data management in more than fifteen future study centers have been established. Discussion Through comprehensive epidemiological, clinical and biological analyses, pedCAPNETZ fills an important gap in pediatric and infection research. To secure dissemination of the registry, we will raise clinical and scientific awareness at all levels. We aim at participating in decision making processes for guidelines and prevention strategies. Ultimately, we hope the results of the pedCAPNETZ registry will help to improve care and quality of life in pedCAP patients in the future. |
| first_indexed | 2024-12-22T06:46:51Z |
| format | Article |
| id | doaj.art-111107085ede4957917c7a4a03c65f34 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-22T06:46:51Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-111107085ede4957917c7a4a03c65f342022-12-21T18:35:15ZengBMCBMC Pulmonary Medicine1471-24662019-12-011911710.1186/s12890-019-1013-5PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescentsMartin Wetzke0Matthias Volkmar Kopp1Jürgen Seidenberg2Christian Vogelberg3Tobias Ankermann4Christine Happle5Gesche Voigt6Holger Köster7Thomas Illig8Christiane Lex9Antje Schuster10Marcus Panning11Grit Barten12Gernot Rohde13Tobias Welte14Gesine Hansen15pedCAPNETZ Study GroupDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical SchoolGerman Center for Lung Research DZL, Airway Center North (ARCN) Lübeck and Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH)Department of Pediatric Pneumology and Allergology, Universitätsklinik für Kinder- und Jugendmedizin OldenburgUniversity Children’s Hospital, Technical University DresdenDepartment of Pediatric Pulmonology, Clinic of Pediatrics UKSH, University of KielDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical SchoolGerman Center for Lung Research DZL, Airway Center North (ARCN) Lübeck and Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH)Department of Pediatric Pneumology and Allergology, Universitätsklinik für Kinder- und Jugendmedizin OldenburgGerman Center for Lung Research DZL, Airway Center North (ARCN) Lübeck and Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH)Department of Pediatric Pulmonology, University of GöttingenDepartment of Pediatric Pulmonology, University of DüsseldorfInstitute of Virology, University of FreiburgGerman Center for Lung Research DZL, Airway Center North (ARCN) Lübeck and Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH)CAPNETZ FoundationGerman Center for Lung Research DZL, Airway Center North (ARCN) Lübeck and Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH)Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical SchoolAbstract Background Pediatric community acquired pneumonia (pedCAP) is one of the leading causes for childhood morbidity accounting for up to 20% of pediatric hospital admissions in high income countries. In spite of its high morbidity, updated epidemiological and pathogen data after introduction of preventive vaccination and novel pathogen screening strategies are limited. Moreover, there is a need for validated recommendations on diagnostic and treatment regimens in pedCAP. Through collection of patient data and analysis of pathogen and host factors in a large sample of unselected pedCAP patients in Germany, we aim to address and substantially improve this situation. Methods pedCAPNETZ is an observational, multi-center study on pedCAP. Thus far, nine study centers in hospitals, outpatient clinics and practices have been initiated and more than 400 patients with radiologically confirmed pneumonia have been enrolled, aiming at a total of 1000 study participants. Employing an online data base, information on disease course, treatment as well as demographical and socioeconomical data is recorded. Patients are followed up until day 90 after enrollment; Comprehensive biosample collection and a central pedCAPNETZ biobank allow for in-depth analyses of pathogen and host factors. Standardized workflows to assure sample logistics and data management in more than fifteen future study centers have been established. Discussion Through comprehensive epidemiological, clinical and biological analyses, pedCAPNETZ fills an important gap in pediatric and infection research. To secure dissemination of the registry, we will raise clinical and scientific awareness at all levels. We aim at participating in decision making processes for guidelines and prevention strategies. Ultimately, we hope the results of the pedCAPNETZ registry will help to improve care and quality of life in pedCAP patients in the future.https://doi.org/10.1186/s12890-019-1013-5 |
| spellingShingle | Martin Wetzke Matthias Volkmar Kopp Jürgen Seidenberg Christian Vogelberg Tobias Ankermann Christine Happle Gesche Voigt Holger Köster Thomas Illig Christiane Lex Antje Schuster Marcus Panning Grit Barten Gernot Rohde Tobias Welte Gesine Hansen pedCAPNETZ Study Group PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents BMC Pulmonary Medicine |
| title | PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents |
| title_full | PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents |
| title_fullStr | PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents |
| title_full_unstemmed | PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents |
| title_short | PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents |
| title_sort | pedcapnetz prospective observational study on community acquired pneumonia in children and adolescents |
| url | https://doi.org/10.1186/s12890-019-1013-5 |
| work_keys_str_mv | AT martinwetzke pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT matthiasvolkmarkopp pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT jurgenseidenberg pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT christianvogelberg pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT tobiasankermann pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT christinehapple pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT geschevoigt pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT holgerkoster pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT thomasillig pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT christianelex pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT antjeschuster pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT marcuspanning pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT gritbarten pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT gernotrohde pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT tobiaswelte pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT gesinehansen pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents AT pedcapnetzstudygroup pedcapnetzprospectiveobservationalstudyoncommunityacquiredpneumoniainchildrenandadolescents |