Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma
ObjectivesTo explore the relationship between ultrasound (US) features and Ki-67 labeling index (LI) of soft tissue sarcoma (STS).MethodsForty-six patients with 47 STS lesions, between September 2014 and April 2020, were enrolled in the study. Point-biserial correlation analysis and Spearman’s corre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.687878/full |
| _version_ | 1819083821448953856 |
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| author | Pingping Wang Hai Li Yu Hu Xiaojing Peng Xinhua Ye Di Xu Ao Li |
| author_facet | Pingping Wang Hai Li Yu Hu Xiaojing Peng Xinhua Ye Di Xu Ao Li |
| author_sort | Pingping Wang |
| collection | DOAJ |
| description | ObjectivesTo explore the relationship between ultrasound (US) features and Ki-67 labeling index (LI) of soft tissue sarcoma (STS).MethodsForty-six patients with 47 STS lesions, between September 2014 and April 2020, were enrolled in the study. Point-biserial correlation analysis and Spearman’s correlation analysis were utilized to examining the relationship between the US features and the Ki-67 LI of STS. The differences of US features between high and low Ki-67 proliferation groups were statistically analyzed by independent t test, Wilcoxon rank-sum test, and Fisher’s exact test. The optimal cut-off points of US features revealing significant differences were estimated by the maximum Youden index.ResultsA moderate correlation between the vascular density grade and the Ki-67 LI (ρ = 0.409, P = 0.004) was found in this study. In addition, other ultrasound features were irrelevant to the Ki-67 LI. The cut-off for differentiating low- and high-proliferation groups was grade II according to the best Youden index. The area under receiver operating characteristic (ROC) curve was 0.74 (p = 0.011) with a sensitivity of 60.6% and specificity of 78.6%.ConclusionsOnly the vascular density grade of STS had a weak positive correlation with Ki-67 LI, and might be capable of predicting the proliferation of STS. Other ultrasonographic features of STS such as shape and tumor margin have no correlation with Ki-67 LI. |
| first_indexed | 2024-12-21T20:38:39Z |
| format | Article |
| id | doaj.art-1112372da9d3448d84aa72c350657863 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T20:38:39Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1112372da9d3448d84aa72c3506578632022-12-21T18:51:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.687878687878Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue SarcomaPingping Wang0Hai Li1Yu Hu2Xiaojing Peng3Xinhua Ye4Di Xu5Ao Li6Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaObjectivesTo explore the relationship between ultrasound (US) features and Ki-67 labeling index (LI) of soft tissue sarcoma (STS).MethodsForty-six patients with 47 STS lesions, between September 2014 and April 2020, were enrolled in the study. Point-biserial correlation analysis and Spearman’s correlation analysis were utilized to examining the relationship between the US features and the Ki-67 LI of STS. The differences of US features between high and low Ki-67 proliferation groups were statistically analyzed by independent t test, Wilcoxon rank-sum test, and Fisher’s exact test. The optimal cut-off points of US features revealing significant differences were estimated by the maximum Youden index.ResultsA moderate correlation between the vascular density grade and the Ki-67 LI (ρ = 0.409, P = 0.004) was found in this study. In addition, other ultrasound features were irrelevant to the Ki-67 LI. The cut-off for differentiating low- and high-proliferation groups was grade II according to the best Youden index. The area under receiver operating characteristic (ROC) curve was 0.74 (p = 0.011) with a sensitivity of 60.6% and specificity of 78.6%.ConclusionsOnly the vascular density grade of STS had a weak positive correlation with Ki-67 LI, and might be capable of predicting the proliferation of STS. Other ultrasonographic features of STS such as shape and tumor margin have no correlation with Ki-67 LI.https://www.frontiersin.org/articles/10.3389/fonc.2021.687878/fullultrasonographyKi-67soft tissue sarcomamusculoskeletalimmunohistochemistry |
| spellingShingle | Pingping Wang Hai Li Yu Hu Xiaojing Peng Xinhua Ye Di Xu Ao Li Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma Frontiers in Oncology ultrasonography Ki-67 soft tissue sarcoma musculoskeletal immunohistochemistry |
| title | Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma |
| title_full | Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma |
| title_fullStr | Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma |
| title_full_unstemmed | Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma |
| title_short | Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma |
| title_sort | relationship between ultrasound features and ki 67 labeling index of soft tissue sarcoma |
| topic | ultrasonography Ki-67 soft tissue sarcoma musculoskeletal immunohistochemistry |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.687878/full |
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