Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons

Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons

Abstract Background Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previ...

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Bibliographic Details
Main Authors: Johanna Heider, Aaron Stahl, Denise Sperlich, Sophia-Marie Hartmann, Sabrina Vogel, Ricarda Breitmeyer, Markus Templin, Hansjürgen Volkmer
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Neuroscience
Subjects:
DISC1
E/I imbalance
GABAergic neurons
Glutamatergic neurons
iPSC
Co-culture
Online Access:https://doi.org/10.1186/s12868-024-00858-z

Internet

https://doi.org/10.1186/s12868-024-00858-z

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