Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia
<h4>Purpose</h4> To evaluate glaucoma diagnostic performance of ganglion cell inner plexiform layer and retinal nerve fiber layer parameters measured with cirrus HD optical coherence tomography (OCT). <h4>Method</h4> Total of 188 eyes were included in our study. 49 eyes of he...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888678/?tool=EBI |
| _version_ | 1811173515679760384 |
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| author | Addishiwot Abera Girum W. Gessesse |
| author_facet | Addishiwot Abera Girum W. Gessesse |
| author_sort | Addishiwot Abera |
| collection | DOAJ |
| description | <h4>Purpose</h4> To evaluate glaucoma diagnostic performance of ganglion cell inner plexiform layer and retinal nerve fiber layer parameters measured with cirrus HD optical coherence tomography (OCT). <h4>Method</h4> Total of 188 eyes were included in our study. 49 eyes of healthy controls, 70 glaucoma suspect eyes and 69 early glaucomatous eyes. Complete ophthalmic examination was done including visual field test (with Humphrey field analyzer) and OCT scanning of ganglion cell inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) in different quadrants. Sensitivity, specificity and area under the receiver operating characteristic curve (AUROC) of each parameter was calculated to provide diagnostic ability between normal controls, glaucoma suspects or early glaucoma. <h4>Result</h4> GCIPL and RNFL parameters had strong power in discriminating early glaucoma from healthy controls with all having AUROC of above 0.76. Of all the GCIPL and RNFL parameters, the only variable that could discriminate between glaucoma suspect and healthy controls was the combined parameter by OR-logic approach. Of all the parameters, the average and nasal RNFL parameters had the strongest power in discriminating between the two with AUROC of 0.81. All parameters had an overall good diagnostic performance with excellent sensitivity but the specificity was relatively poor. The combined parameter had the best specificity (62.2%) with excellent sensitivity (93.5%). <h4>Conclusion</h4> Nasal RNFL parameters had the strongest power in discriminating between glaucoma suspect and healthy controls and the OR-logic combination of RNFL and GCIPL provides better diagnostic performance than single GCIPL, RNFL or ONH parameter. |
| first_indexed | 2024-04-10T17:48:17Z |
| format | Article |
| id | doaj.art-11147564e857444298319337ac377fc3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T17:48:17Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-11147564e857444298319337ac377fc32023-02-02T22:58:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, EthiopiaAddishiwot AberaGirum W. Gessesse<h4>Purpose</h4> To evaluate glaucoma diagnostic performance of ganglion cell inner plexiform layer and retinal nerve fiber layer parameters measured with cirrus HD optical coherence tomography (OCT). <h4>Method</h4> Total of 188 eyes were included in our study. 49 eyes of healthy controls, 70 glaucoma suspect eyes and 69 early glaucomatous eyes. Complete ophthalmic examination was done including visual field test (with Humphrey field analyzer) and OCT scanning of ganglion cell inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) in different quadrants. Sensitivity, specificity and area under the receiver operating characteristic curve (AUROC) of each parameter was calculated to provide diagnostic ability between normal controls, glaucoma suspects or early glaucoma. <h4>Result</h4> GCIPL and RNFL parameters had strong power in discriminating early glaucoma from healthy controls with all having AUROC of above 0.76. Of all the GCIPL and RNFL parameters, the only variable that could discriminate between glaucoma suspect and healthy controls was the combined parameter by OR-logic approach. Of all the parameters, the average and nasal RNFL parameters had the strongest power in discriminating between the two with AUROC of 0.81. All parameters had an overall good diagnostic performance with excellent sensitivity but the specificity was relatively poor. The combined parameter had the best specificity (62.2%) with excellent sensitivity (93.5%). <h4>Conclusion</h4> Nasal RNFL parameters had the strongest power in discriminating between glaucoma suspect and healthy controls and the OR-logic combination of RNFL and GCIPL provides better diagnostic performance than single GCIPL, RNFL or ONH parameter.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888678/?tool=EBI |
| spellingShingle | Addishiwot Abera Girum W. Gessesse Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia PLoS ONE |
| title | Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia |
| title_full | Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia |
| title_fullStr | Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia |
| title_full_unstemmed | Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia |
| title_short | Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia |
| title_sort | diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at st paul s hospital millennium medical college addis ababa ethiopia |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888678/?tool=EBI |
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