Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study
Abstract Background Cognitive functions represent useful endophenotypes to identify the association between genetic variants and schizophrenia. In this sense, the NR4A2 gene has been implicated in schizophrenia and cognition in different animal models and clinical trials. We hypothesized that the NR...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-021-03081-w |
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| author | Elizabeth Ruiz-Sánchez Janet Jiménez-Genchi Yessica M. Alcántara-Flores Carlos J. Castañeda-González Carlos L. Aviña-Cervantes Petra Yescas María del Socorro González-Valadez Nancy Martínez-Rodríguez Antonio Ríos-Ortiz Martha González-González María E. López-Navarro Patricia Rojas |
| author_facet | Elizabeth Ruiz-Sánchez Janet Jiménez-Genchi Yessica M. Alcántara-Flores Carlos J. Castañeda-González Carlos L. Aviña-Cervantes Petra Yescas María del Socorro González-Valadez Nancy Martínez-Rodríguez Antonio Ríos-Ortiz Martha González-González María E. López-Navarro Patricia Rojas |
| author_sort | Elizabeth Ruiz-Sánchez |
| collection | DOAJ |
| description | Abstract Background Cognitive functions represent useful endophenotypes to identify the association between genetic variants and schizophrenia. In this sense, the NR4A2 gene has been implicated in schizophrenia and cognition in different animal models and clinical trials. We hypothesized that the NR4A2 gene is associated with working memory performance in schizophrenia. This study aimed to analyze two variants and the expression levels of the NR4A2 gene with susceptibility to schizophrenia, as well as to evaluate whether possession of NR4A2 variants influence the possible correlation between gene expression and working memory performance in schizophrenia. Methods The current study included 187 schizophrenia patients and 227 controls genotyped for two of the most studied NR4A2 genetic variants in neurological and neuropsychiatric diseases. Genotyping was performed using High Resolution Melt and sequencing techniques. In addition, mRNA expression of NR4A2 was performed in peripheral mononuclear cells of 112 patients and 118 controls. A group of these participants, 54 patients and 87 controls, performed the working memory index of the WAIS III test. Results Both genotypic frequencies of the two variants and expression levels of the NR4A2 gene showed no significant difference when in patients versus controls. However, patients homozygous for the rs34884856 promoter variant showed a positive correlation between expression levels and auditory working memory. Conclusions Our finding suggested that changes in expression levels of the NR4A2 gene could be associated with working memory in schizophrenia depending on patients’ genotype in a sample from a Mexican population. |
| first_indexed | 2024-12-20T08:09:40Z |
| format | Article |
| id | doaj.art-1114cc9207a44e3fad93c8798f515ccb |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-20T08:09:40Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-1114cc9207a44e3fad93c8798f515ccb2022-12-21T19:47:18ZengBMCBMC Psychiatry1471-244X2021-02-0121111310.1186/s12888-021-03081-wWorking memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control studyElizabeth Ruiz-Sánchez0Janet Jiménez-Genchi1Yessica M. Alcántara-Flores2Carlos J. Castañeda-González3Carlos L. Aviña-Cervantes4Petra Yescas5María del Socorro González-Valadez6Nancy Martínez-Rodríguez7Antonio Ríos-Ortiz8Martha González-González9María E. López-Navarro10Patricia Rojas11Laboratory of Neurotoxicology, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, SSResearch Unit, Hospital Psiquiátrico Fray Bernardino ÁlvarezLaboratory of Neurotoxicology, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, SSGeneral Direction, Hospital Psiquiátrico Fray Bernardino ÁlvarezDepartment of Psychiatry, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, SSDepartment of Genetics, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, SSHealth Care Division, Hospital Psiquiátrico Fray Bernardino ÁlvarezEpidemiology, Endocrinology & Nutrition Research Unit, Hospital Infantil de México “Federico Gómez”Research Unit, Hospital Psiquiátrico Fray Bernardino ÁlvarezUnit of Cognition and Behavior, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, SSLaboratory of Neurotoxicology, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, SSLaboratory of Neurotoxicology, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, SSAbstract Background Cognitive functions represent useful endophenotypes to identify the association between genetic variants and schizophrenia. In this sense, the NR4A2 gene has been implicated in schizophrenia and cognition in different animal models and clinical trials. We hypothesized that the NR4A2 gene is associated with working memory performance in schizophrenia. This study aimed to analyze two variants and the expression levels of the NR4A2 gene with susceptibility to schizophrenia, as well as to evaluate whether possession of NR4A2 variants influence the possible correlation between gene expression and working memory performance in schizophrenia. Methods The current study included 187 schizophrenia patients and 227 controls genotyped for two of the most studied NR4A2 genetic variants in neurological and neuropsychiatric diseases. Genotyping was performed using High Resolution Melt and sequencing techniques. In addition, mRNA expression of NR4A2 was performed in peripheral mononuclear cells of 112 patients and 118 controls. A group of these participants, 54 patients and 87 controls, performed the working memory index of the WAIS III test. Results Both genotypic frequencies of the two variants and expression levels of the NR4A2 gene showed no significant difference when in patients versus controls. However, patients homozygous for the rs34884856 promoter variant showed a positive correlation between expression levels and auditory working memory. Conclusions Our finding suggested that changes in expression levels of the NR4A2 gene could be associated with working memory in schizophrenia depending on patients’ genotype in a sample from a Mexican population.https://doi.org/10.1186/s12888-021-03081-wSchizophreniaNR4A2 genetic variantsNR4A2 mRNA levelsCognitionEndophenotypeWorking memory |
| spellingShingle | Elizabeth Ruiz-Sánchez Janet Jiménez-Genchi Yessica M. Alcántara-Flores Carlos J. Castañeda-González Carlos L. Aviña-Cervantes Petra Yescas María del Socorro González-Valadez Nancy Martínez-Rodríguez Antonio Ríos-Ortiz Martha González-González María E. López-Navarro Patricia Rojas Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study BMC Psychiatry Schizophrenia NR4A2 genetic variants NR4A2 mRNA levels Cognition Endophenotype Working memory |
| title | Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study |
| title_full | Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study |
| title_fullStr | Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study |
| title_full_unstemmed | Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study |
| title_short | Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study |
| title_sort | working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the nr4a2 gene in a sample mexican population a case control study |
| topic | Schizophrenia NR4A2 genetic variants NR4A2 mRNA levels Cognition Endophenotype Working memory |
| url | https://doi.org/10.1186/s12888-021-03081-w |
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