A mitochondrial megachannel resides in monomeric F1FO ATP synthase
The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels with the key features of mPTP.
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13766-2 |