A mitochondrial megachannel resides in monomeric F1FO ATP synthase
The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels with the key features of mPTP.
Main Authors: | Nelli Mnatsakanyan, Marc C. Llaguno, Youshan Yang, Yangyang Yan, Joachim Weber, Fred J. Sigworth, Elizabeth A. Jonas |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2019-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-13766-2 |
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