Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp.
Bacterial and fungal biofilm has increased antibiotic resistance and plays an essential role in many persistent diseases. Biofilm-associated chronic infections are difficult to treat and reduce the efficacy of medical devices. This global problem has prompted extensive research to find alternative s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/11/1531 |
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| author | Graziana Bonincontro Sarah Adriana Scuderi Andreana Marino Giovanna Simonetti |
| author_facet | Graziana Bonincontro Sarah Adriana Scuderi Andreana Marino Giovanna Simonetti |
| author_sort | Graziana Bonincontro |
| collection | DOAJ |
| description | Bacterial and fungal biofilm has increased antibiotic resistance and plays an essential role in many persistent diseases. Biofilm-associated chronic infections are difficult to treat and reduce the efficacy of medical devices. This global problem has prompted extensive research to find alternative strategies to fight microbial chronic infections. Plant bioactive metabolites with antibiofilm activity are known to be potential resources to alleviate this problem. The phytochemical screening of some medicinal plants showed different active groups, such as stilbenes, tannins, alkaloids, terpenes, polyphenolics, flavonoids, lignans, quinones, and coumarins. Synergistic effects can be observed in the interaction between plant compounds and conventional drugs. This review analyses and summarises the current knowledge on the synergistic effects of plant metabolites in combination with conventional antimicrobials against biofilms of <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>. The synergism of conventional antimicrobials with plant compounds can modify and inhibit the mechanisms of acquired resistance, reduce undesirable effects, and obtain an appropriate therapeutic effect at lower doses. A deeper knowledge of these combinations and of their possible antibiofilm targets is needed to develop next-generation novel antimicrobials and/or improve current antimicrobials to fight drug-resistant infections attributed to biofilm. |
| first_indexed | 2024-03-09T16:32:00Z |
| format | Article |
| id | doaj.art-11157a35754240b28c9117b84609e2c2 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T16:32:00Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-11157a35754240b28c9117b84609e2c22023-11-24T15:00:05ZengMDPI AGPharmaceuticals1424-82472023-10-011611153110.3390/ph16111531Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp.Graziana Bonincontro0Sarah Adriana Scuderi1Andreana Marino2Giovanna Simonetti3Department of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Roma, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 98100 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 98100 Messina, ItalyDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Roma, ItalyBacterial and fungal biofilm has increased antibiotic resistance and plays an essential role in many persistent diseases. Biofilm-associated chronic infections are difficult to treat and reduce the efficacy of medical devices. This global problem has prompted extensive research to find alternative strategies to fight microbial chronic infections. Plant bioactive metabolites with antibiofilm activity are known to be potential resources to alleviate this problem. The phytochemical screening of some medicinal plants showed different active groups, such as stilbenes, tannins, alkaloids, terpenes, polyphenolics, flavonoids, lignans, quinones, and coumarins. Synergistic effects can be observed in the interaction between plant compounds and conventional drugs. This review analyses and summarises the current knowledge on the synergistic effects of plant metabolites in combination with conventional antimicrobials against biofilms of <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>. The synergism of conventional antimicrobials with plant compounds can modify and inhibit the mechanisms of acquired resistance, reduce undesirable effects, and obtain an appropriate therapeutic effect at lower doses. A deeper knowledge of these combinations and of their possible antibiofilm targets is needed to develop next-generation novel antimicrobials and/or improve current antimicrobials to fight drug-resistant infections attributed to biofilm.https://www.mdpi.com/1424-8247/16/11/1531antimicrobials<i>Candida</i> spp.microbial biofilmplant compounds<i>Pseudomonas aeruginosa</i><i>Staphylococcus aureus</i> |
| spellingShingle | Graziana Bonincontro Sarah Adriana Scuderi Andreana Marino Giovanna Simonetti Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp. Pharmaceuticals antimicrobials <i>Candida</i> spp. microbial biofilm plant compounds <i>Pseudomonas aeruginosa</i> <i>Staphylococcus aureus</i> |
| title | Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp. |
| title_full | Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp. |
| title_fullStr | Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp. |
| title_full_unstemmed | Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp. |
| title_short | Synergistic Effect of Plant Compounds in Combination with Conventional Antimicrobials against Biofilm of <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Candida</i> spp. |
| title_sort | synergistic effect of plant compounds in combination with conventional antimicrobials against biofilm of i staphylococcus aureus pseudomonas aeruginosa i and i candida i spp |
| topic | antimicrobials <i>Candida</i> spp. microbial biofilm plant compounds <i>Pseudomonas aeruginosa</i> <i>Staphylococcus aureus</i> |
| url | https://www.mdpi.com/1424-8247/16/11/1531 |
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