Modulatory effects of the piccolo genotype on emotional memory in health and depression.
Major depressive disorder (MDD) has been associated with biased memory formation for mood-congruent information, which may be related to altered monoamine levels. The piccolo (PCLO) gene, involved in monoaminergic neurotransmission, has previously been linked to depression in a genome-wide associati...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3631241?pdf=render |
| _version_ | 1828318443749769216 |
|---|---|
| author | Saskia Woudstra Marie-José van Tol Zoltán Bochdanovits Nic J van der Wee Frans G Zitman Mark A van Buchem Esther M Opmeer André Aleman Brenda W Penninx Dick J Veltman Witte J Hoogendijk |
| author_facet | Saskia Woudstra Marie-José van Tol Zoltán Bochdanovits Nic J van der Wee Frans G Zitman Mark A van Buchem Esther M Opmeer André Aleman Brenda W Penninx Dick J Veltman Witte J Hoogendijk |
| author_sort | Saskia Woudstra |
| collection | DOAJ |
| description | Major depressive disorder (MDD) has been associated with biased memory formation for mood-congruent information, which may be related to altered monoamine levels. The piccolo (PCLO) gene, involved in monoaminergic neurotransmission, has previously been linked to depression in a genome-wide association study. Here, we investigated the role of the PCLO risk allele on functional magnetic resonance imaging (MRI) correlates of emotional memory in a sample of 89 MDD patients (64 PCLO risk allele carriers) and 29 healthy controls (18 PCLO risk allele carriers). During negative word encoding, risk allele carriers showed significant lower activity relative to non-risk allele carriers in the insula, and trend-wise in the anterior cingulate cortex and inferior frontal gyrus. Moreover, depressed risk allele carriers showed significant lower activity relative to non-risk allele carriers in the striatum, an effect which was absent in healthy controls. Finally, amygdalar response during processing new positive words vs. known words was blunted in healthy PCLO+ carriers and in MDD patients irrespective of genotype, which may indicate that signalling of salient novel information does not occur to the same extent in PCLO+ carriers and MDD patients. The PCLO risk allele may increase vulnerability for MDD by modulating local brain function with regard to responsiveness to salient stimuli (i.e. insula) and processing novel negative information. Also, depression-specific effects of PCLO on dorsal striatal activation during negative word encoding and the absence of amygdalar salience signalling for novel positive information further suggest a role of PCLO in symptom maintenance in MDD. |
| first_indexed | 2024-04-13T17:43:00Z |
| format | Article |
| id | doaj.art-111afbf5b34d48719109a9c6349935da |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T17:43:00Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-111afbf5b34d48719109a9c6349935da2022-12-22T02:37:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6149410.1371/journal.pone.0061494Modulatory effects of the piccolo genotype on emotional memory in health and depression.Saskia WoudstraMarie-José van TolZoltán BochdanovitsNic J van der WeeFrans G ZitmanMark A van BuchemEsther M OpmeerAndré AlemanBrenda W PenninxDick J VeltmanWitte J HoogendijkMajor depressive disorder (MDD) has been associated with biased memory formation for mood-congruent information, which may be related to altered monoamine levels. The piccolo (PCLO) gene, involved in monoaminergic neurotransmission, has previously been linked to depression in a genome-wide association study. Here, we investigated the role of the PCLO risk allele on functional magnetic resonance imaging (MRI) correlates of emotional memory in a sample of 89 MDD patients (64 PCLO risk allele carriers) and 29 healthy controls (18 PCLO risk allele carriers). During negative word encoding, risk allele carriers showed significant lower activity relative to non-risk allele carriers in the insula, and trend-wise in the anterior cingulate cortex and inferior frontal gyrus. Moreover, depressed risk allele carriers showed significant lower activity relative to non-risk allele carriers in the striatum, an effect which was absent in healthy controls. Finally, amygdalar response during processing new positive words vs. known words was blunted in healthy PCLO+ carriers and in MDD patients irrespective of genotype, which may indicate that signalling of salient novel information does not occur to the same extent in PCLO+ carriers and MDD patients. The PCLO risk allele may increase vulnerability for MDD by modulating local brain function with regard to responsiveness to salient stimuli (i.e. insula) and processing novel negative information. Also, depression-specific effects of PCLO on dorsal striatal activation during negative word encoding and the absence of amygdalar salience signalling for novel positive information further suggest a role of PCLO in symptom maintenance in MDD.http://europepmc.org/articles/PMC3631241?pdf=render |
| spellingShingle | Saskia Woudstra Marie-José van Tol Zoltán Bochdanovits Nic J van der Wee Frans G Zitman Mark A van Buchem Esther M Opmeer André Aleman Brenda W Penninx Dick J Veltman Witte J Hoogendijk Modulatory effects of the piccolo genotype on emotional memory in health and depression. PLoS ONE |
| title | Modulatory effects of the piccolo genotype on emotional memory in health and depression. |
| title_full | Modulatory effects of the piccolo genotype on emotional memory in health and depression. |
| title_fullStr | Modulatory effects of the piccolo genotype on emotional memory in health and depression. |
| title_full_unstemmed | Modulatory effects of the piccolo genotype on emotional memory in health and depression. |
| title_short | Modulatory effects of the piccolo genotype on emotional memory in health and depression. |
| title_sort | modulatory effects of the piccolo genotype on emotional memory in health and depression |
| url | http://europepmc.org/articles/PMC3631241?pdf=render |
| work_keys_str_mv | AT saskiawoudstra modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT mariejosevantol modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT zoltanbochdanovits modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT nicjvanderwee modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT fransgzitman modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT markavanbuchem modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT esthermopmeer modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT andrealeman modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT brendawpenninx modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT dickjveltman modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression AT wittejhoogendijk modulatoryeffectsofthepiccologenotypeonemotionalmemoryinhealthanddepression |