Light at the ENDothelium-role of Sox17 and Runx1 in endothelial dysfunction and pulmonary arterial hypertension

Light at the ENDothelium-role of Sox17 and Runx1 in endothelial dysfunction and pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a progressive disease that is characterized by an obliterative vasculopathy of the distal pulmonary circulation. Despite significant progress in our understanding of the pathophysiology, currently approved medical therapies for PAH act primarily as pulmonary...

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Bibliographic Details
Main Authors: Robert Simmons Beck, Olin D. Liang, James R. Klinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
pulmonary hypertension
endothelial dysfunction
transcription factors
SOX17
Runx1
pulmonary vascular remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1274033/full

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