Connexins and Gap Junctions in Cancer of the Urinary Tract
This review focuses on connexins and nexus or gap junctions in the genesis, progression, and therapy of carcinomas of the human urinary tract. Some decades ago, the idea was born that gap junctional intercellular communication might prevent both the onset and the progression of cancer. Later evidenc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/5/704 |
| _version_ | 1797711217497735168 |
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| author | Thomas Tschernig |
| author_facet | Thomas Tschernig |
| author_sort | Thomas Tschernig |
| collection | DOAJ |
| description | This review focuses on connexins and nexus or gap junctions in the genesis, progression, and therapy of carcinomas of the human urinary tract. Some decades ago, the idea was born that gap junctional intercellular communication might prevent both the onset and the progression of cancer. Later evidence indicated that, on the contrary, synthesis and the presence of connexins as a prerequisite for gap junctional intercellular communication might promote the occurrence of cancer and metastases. The research history of urinary bladder cancer is a good example of the development of scientific perception. So far, the role of gap junctional intercellular communication in carcinogenesis and cancer progression, as well as in therapeutical approaches, remains unclear. |
| first_indexed | 2024-03-12T07:02:49Z |
| format | Article |
| id | doaj.art-111baa2c6886423dae6f9517a0a99adf |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:02:49Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-111baa2c6886423dae6f9517a0a99adf2023-09-02T23:35:29ZengMDPI AGCancers2072-66942019-05-0111570410.3390/cancers11050704cancers11050704Connexins and Gap Junctions in Cancer of the Urinary TractThomas Tschernig0Institute for Anatomy and Cell Biology, Medical Faculty, Saarland University, 66421 Homburg/Saar, GermanyThis review focuses on connexins and nexus or gap junctions in the genesis, progression, and therapy of carcinomas of the human urinary tract. Some decades ago, the idea was born that gap junctional intercellular communication might prevent both the onset and the progression of cancer. Later evidence indicated that, on the contrary, synthesis and the presence of connexins as a prerequisite for gap junctional intercellular communication might promote the occurrence of cancer and metastases. The research history of urinary bladder cancer is a good example of the development of scientific perception. So far, the role of gap junctional intercellular communication in carcinogenesis and cancer progression, as well as in therapeutical approaches, remains unclear.https://www.mdpi.com/2072-6694/11/5/704connexinsgap junctionsintercellular communicationhuman urinary tractcancercarcinogenesis |
| spellingShingle | Thomas Tschernig Connexins and Gap Junctions in Cancer of the Urinary Tract Cancers connexins gap junctions intercellular communication human urinary tract cancer carcinogenesis |
| title | Connexins and Gap Junctions in Cancer of the Urinary Tract |
| title_full | Connexins and Gap Junctions in Cancer of the Urinary Tract |
| title_fullStr | Connexins and Gap Junctions in Cancer of the Urinary Tract |
| title_full_unstemmed | Connexins and Gap Junctions in Cancer of the Urinary Tract |
| title_short | Connexins and Gap Junctions in Cancer of the Urinary Tract |
| title_sort | connexins and gap junctions in cancer of the urinary tract |
| topic | connexins gap junctions intercellular communication human urinary tract cancer carcinogenesis |
| url | https://www.mdpi.com/2072-6694/11/5/704 |
| work_keys_str_mv | AT thomastschernig connexinsandgapjunctionsincanceroftheurinarytract |