Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus)
<p class="IsiAbstrakIndo"><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> has been generally known and believed by Lingga Malay society as anti-aging agent. However, the study of </span><em><span lang=&...
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| Format: | Article |
| Language: | English |
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Universitas Negeri Semarang
2017-12-01
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| Series: | Biosaintifika: Journal of Biology & Biology Education |
| Subjects: | |
| Online Access: | https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/10496 |
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| author | Fitmawati Fitmawati Rodesia Mustika Roza Nery Sofiyanti Isnaini Isnaini Febrian Lailatul Fitri Desi Paramita Awal Prichatin Kusumo Dewi |
| author_facet | Fitmawati Fitmawati Rodesia Mustika Roza Nery Sofiyanti Isnaini Isnaini Febrian Lailatul Fitri Desi Paramita Awal Prichatin Kusumo Dewi |
| author_sort | Fitmawati Fitmawati |
| collection | DOAJ |
| description | <p class="IsiAbstrakIndo"><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> has been generally known and believed by Lingga Malay society as anti-aging agent. However, the study of </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> is not scientifically proven. This research was aimed to prove immunomodulatory ability of </span><em><span lang="EN-GB">Obat pahit </span></em><span lang="EN-GB">potion from Lingga, Riau Archipelago. This study used white rats as an animal modelling, and </span><em><span lang="EN-GB">Staphylococcus aureus</span></em><span lang="EN-GB"> as bacteria tester. The rats had been treated with aqueous </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> extract from three TMPs on dose scales of 0.09, 0.18 and 0.27 mL/200g of body weight through oral administration for 7 days. Furthermore, on the 8<sup>th</sup> days, the experiment animals were injected by the preparation of bacteria tester through intraperitoneal administration in the amount of 0.5 mL/200 gram of body weigth and subsequently incubated for 1 hour after the injection. There were 2 observed parameters on this study, i.e efectivity and capacity of phagocytosis by leukocytes. The observation of leukocytes-phagocytocis activity was carried out by making a smear preparat samples of peritoneum fluid from rats. After the observation under microscope on a magnification of 100 times. The result was obtained the </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> from Kalan PMT swere more effective on dose 2, while from SP4 and Linau TMPs were much more effective on dose 1. It is therefore, using these data of the results, the advanced doses scale of this </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> would not be necessary. </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> potion from Malay Lingga Malay Ethnic could become raw materials of immunomodulatory herbal medicine based on traditional knowledge. It also potentially as a standardized herbal.</span></p> |
| first_indexed | 2024-12-23T13:46:25Z |
| format | Article |
| id | doaj.art-111be6c790994bd8b82e96287f95bf11 |
| institution | Directory Open Access Journal |
| issn | 2085-191X 2338-7610 |
| language | English |
| last_indexed | 2024-12-23T13:46:25Z |
| publishDate | 2017-12-01 |
| publisher | Universitas Negeri Semarang |
| record_format | Article |
| series | Biosaintifika: Journal of Biology & Biology Education |
| spelling | doaj.art-111be6c790994bd8b82e96287f95bf112022-12-21T17:44:42ZengUniversitas Negeri SemarangBiosaintifika: Journal of Biology & Biology Education2085-191X2338-76102017-12-019343043610.15294/biosaintifika.v9i3.104966530Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus)Fitmawati Fitmawati0Rodesia Mustika Roza1Nery Sofiyanti2Isnaini Isnaini3Febrian Lailatul Fitri4Desi Paramita5Awal Prichatin Kusumo Dewi6Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas RiauDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas RiauDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas RiauLaboratory of Plant Biotechnology, Faculty of Agriculture, Universitas RiauDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas RiauDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas RiauCenter for Research and Development of Medicinal Plants and Traditional Medicine Tawangmangu, Indonesia<p class="IsiAbstrakIndo"><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> has been generally known and believed by Lingga Malay society as anti-aging agent. However, the study of </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> is not scientifically proven. This research was aimed to prove immunomodulatory ability of </span><em><span lang="EN-GB">Obat pahit </span></em><span lang="EN-GB">potion from Lingga, Riau Archipelago. This study used white rats as an animal modelling, and </span><em><span lang="EN-GB">Staphylococcus aureus</span></em><span lang="EN-GB"> as bacteria tester. The rats had been treated with aqueous </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> extract from three TMPs on dose scales of 0.09, 0.18 and 0.27 mL/200g of body weight through oral administration for 7 days. Furthermore, on the 8<sup>th</sup> days, the experiment animals were injected by the preparation of bacteria tester through intraperitoneal administration in the amount of 0.5 mL/200 gram of body weigth and subsequently incubated for 1 hour after the injection. There were 2 observed parameters on this study, i.e efectivity and capacity of phagocytosis by leukocytes. The observation of leukocytes-phagocytocis activity was carried out by making a smear preparat samples of peritoneum fluid from rats. After the observation under microscope on a magnification of 100 times. The result was obtained the </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> from Kalan PMT swere more effective on dose 2, while from SP4 and Linau TMPs were much more effective on dose 1. It is therefore, using these data of the results, the advanced doses scale of this </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> would not be necessary. </span><em><span lang="EN-GB">Obat pahit</span></em><span lang="EN-GB"> potion from Malay Lingga Malay Ethnic could become raw materials of immunomodulatory herbal medicine based on traditional knowledge. It also potentially as a standardized herbal.</span></p>https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/10496ImmunomodulatoryLinggaRiau ArchipelagoObat pahit |
| spellingShingle | Fitmawati Fitmawati Rodesia Mustika Roza Nery Sofiyanti Isnaini Isnaini Febrian Lailatul Fitri Desi Paramita Awal Prichatin Kusumo Dewi Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus) Biosaintifika: Journal of Biology & Biology Education Immunomodulatory Lingga Riau Archipelago Obat pahit |
| title | Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus) |
| title_full | Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus) |
| title_fullStr | Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus) |
| title_full_unstemmed | Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus) |
| title_short | Immunomodulatory Effectiveness of Aqueous Obat Pahit Extract of Lingga Malay Ethnic on White Rats (Rattus novergicus) |
| title_sort | immunomodulatory effectiveness of aqueous obat pahit extract of lingga malay ethnic on white rats rattus novergicus |
| topic | Immunomodulatory Lingga Riau Archipelago Obat pahit |
| url | https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/10496 |
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