Rho GTPases Signaling in Zebrafish Development and Disease
Cells encounter countless external cues and the specificity of their responses is translated through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a central role and transduce signals that contribute to fundamental cell dynamic and survival events. Here, we review o...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/12/2634 |
| _version_ | 1797545425934221312 |
|---|---|
| author | Marie-José Boueid Aya Mikdache Emilie Lesport Cindy Degerny Marcel Tawk |
| author_facet | Marie-José Boueid Aya Mikdache Emilie Lesport Cindy Degerny Marcel Tawk |
| author_sort | Marie-José Boueid |
| collection | DOAJ |
| description | Cells encounter countless external cues and the specificity of their responses is translated through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a central role and transduce signals that contribute to fundamental cell dynamic and survival events. Here, we review our knowledge on how zebrafish helped us understand the role of some of these proteins in a multitude of in vivo cellular behaviors. Zebrafish studies offer a unique opportunity to explore the role and more specifically the spatial and temporal dynamic of Rho GTPases activities within a complex environment at a level of details unachievable in any other vertebrate organism. |
| first_indexed | 2024-03-10T14:15:14Z |
| format | Article |
| id | doaj.art-111bf6c3a8a54f108bcf69ba49a9e725 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:15:14Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-111bf6c3a8a54f108bcf69ba49a9e7252023-11-20T23:50:41ZengMDPI AGCells2073-44092020-12-01912263410.3390/cells9122634Rho GTPases Signaling in Zebrafish Development and DiseaseMarie-José Boueid0Aya Mikdache1Emilie Lesport2Cindy Degerny3Marcel Tawk4Université Paris-Saclay, Hôpital Kremlin Bicêtre, U1195, Inserm, 94276 Le Kremlin Bicêtre, FranceUniversité Paris-Saclay, Hôpital Kremlin Bicêtre, U1195, Inserm, 94276 Le Kremlin Bicêtre, FranceUniversité Paris-Saclay, Hôpital Kremlin Bicêtre, U1195, Inserm, 94276 Le Kremlin Bicêtre, FranceUniversité Paris-Saclay, Hôpital Kremlin Bicêtre, U1195, Inserm, 94276 Le Kremlin Bicêtre, FranceUniversité Paris-Saclay, Hôpital Kremlin Bicêtre, U1195, Inserm, 94276 Le Kremlin Bicêtre, FranceCells encounter countless external cues and the specificity of their responses is translated through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a central role and transduce signals that contribute to fundamental cell dynamic and survival events. Here, we review our knowledge on how zebrafish helped us understand the role of some of these proteins in a multitude of in vivo cellular behaviors. Zebrafish studies offer a unique opportunity to explore the role and more specifically the spatial and temporal dynamic of Rho GTPases activities within a complex environment at a level of details unachievable in any other vertebrate organism.https://www.mdpi.com/2073-4409/9/12/2634zebrafishsmall GTPasesRacCdc42RhoAGEF |
| spellingShingle | Marie-José Boueid Aya Mikdache Emilie Lesport Cindy Degerny Marcel Tawk Rho GTPases Signaling in Zebrafish Development and Disease Cells zebrafish small GTPases Rac Cdc42 RhoA GEF |
| title | Rho GTPases Signaling in Zebrafish Development and Disease |
| title_full | Rho GTPases Signaling in Zebrafish Development and Disease |
| title_fullStr | Rho GTPases Signaling in Zebrafish Development and Disease |
| title_full_unstemmed | Rho GTPases Signaling in Zebrafish Development and Disease |
| title_short | Rho GTPases Signaling in Zebrafish Development and Disease |
| title_sort | rho gtpases signaling in zebrafish development and disease |
| topic | zebrafish small GTPases Rac Cdc42 RhoA GEF |
| url | https://www.mdpi.com/2073-4409/9/12/2634 |
| work_keys_str_mv | AT mariejoseboueid rhogtpasessignalinginzebrafishdevelopmentanddisease AT ayamikdache rhogtpasessignalinginzebrafishdevelopmentanddisease AT emilielesport rhogtpasessignalinginzebrafishdevelopmentanddisease AT cindydegerny rhogtpasessignalinginzebrafishdevelopmentanddisease AT marceltawk rhogtpasessignalinginzebrafishdevelopmentanddisease |