Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine
Ventricular assist devices (VADs) are used to provide mechanical circulatory support to patients with end-stage heart failure. The driveline connecting the external power source to the pump(s) of the intra-corporal VAD breaches the protective skin barrier and provides a track for microbes to invade...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/9/1/18 |
| _version_ | 1827664879933194240 |
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| author | Johannes Weichsel Benito Baldauf Hendrik Bonnemeier Ernest W. Lau Sven Dittrich Robert Cesnjevar |
| author_facet | Johannes Weichsel Benito Baldauf Hendrik Bonnemeier Ernest W. Lau Sven Dittrich Robert Cesnjevar |
| author_sort | Johannes Weichsel |
| collection | DOAJ |
| description | Ventricular assist devices (VADs) are used to provide mechanical circulatory support to patients with end-stage heart failure. The driveline connecting the external power source to the pump(s) of the intra-corporal VAD breaches the protective skin barrier and provides a track for microbes to invade the interior of the patient’s body. Driveline infection constitutes a major and potentially fatal vulnerability of VAD therapy. Driveline infection cannot traditionally be salvaged and requires the extraction of the entire VAD system. We report here the successful eradication of a VAD driveline infection with a taurolidine-containing antimicrobial solution used for preventing the infection of cardiac implantable electronic devices. If replicated in more cases, the novel treatment concept described here may provide a valuable alternative management strategy of salvage rather than explantation for VAD driveline infection. |
| first_indexed | 2024-03-10T01:14:49Z |
| format | Article |
| id | doaj.art-111ce62dd1344900acf02d21d2c0d086 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T01:14:49Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-111ce62dd1344900acf02d21d2c0d0862023-11-23T14:11:10ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-01-01911810.3390/jcdd9010018Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with TaurolidineJohannes Weichsel0Benito Baldauf1Hendrik Bonnemeier2Ernest W. Lau3Sven Dittrich4Robert Cesnjevar5Department of Paediatric Cardiology, University Hospital Erlangen, 91054 Erlangen, GermanyMedical Faculty, Christian-Albrechts University Kiel, 24118 Kiel, GermanyMedical Faculty, Christian-Albrechts University Kiel, 24118 Kiel, GermanyDepartment of Cardiology, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UKDepartment of Paediatric Cardiology, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Paediatric Cardiothoracic Surgery, University Hospital Erlangen, 91054 Erlangen, GermanyVentricular assist devices (VADs) are used to provide mechanical circulatory support to patients with end-stage heart failure. The driveline connecting the external power source to the pump(s) of the intra-corporal VAD breaches the protective skin barrier and provides a track for microbes to invade the interior of the patient’s body. Driveline infection constitutes a major and potentially fatal vulnerability of VAD therapy. Driveline infection cannot traditionally be salvaged and requires the extraction of the entire VAD system. We report here the successful eradication of a VAD driveline infection with a taurolidine-containing antimicrobial solution used for preventing the infection of cardiac implantable electronic devices. If replicated in more cases, the novel treatment concept described here may provide a valuable alternative management strategy of salvage rather than explantation for VAD driveline infection.https://www.mdpi.com/2308-3425/9/1/18left ventricular assist deviceinfectiondrivelinetaurolidine |
| spellingShingle | Johannes Weichsel Benito Baldauf Hendrik Bonnemeier Ernest W. Lau Sven Dittrich Robert Cesnjevar Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine Journal of Cardiovascular Development and Disease left ventricular assist device infection driveline taurolidine |
| title | Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine |
| title_full | Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine |
| title_fullStr | Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine |
| title_full_unstemmed | Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine |
| title_short | Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine |
| title_sort | eradication of ventricular assist device driveline infection in paediatric patients with taurolidine |
| topic | left ventricular assist device infection driveline taurolidine |
| url | https://www.mdpi.com/2308-3425/9/1/18 |
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