Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand
Prosthetic implants are widely used in dentistry and orthopedics and, as a result, infections can occur which cause their removal. Therefore, it is essential to propose methods of eradicating the bacteria that remain on the prosthesis during treatment. For this purpose, it is necessary to develop su...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/4/2183 |
| _version_ | 1797479291592638464 |
|---|---|
| author | Serena Carrara Florent Rouvier Sanjana Auditto Frédéric Brunel Charlotte Jeanneau Michel Camplo Michelle Sergent Imad About Jean-Michel Bolla Jean-Manuel Raimundo |
| author_facet | Serena Carrara Florent Rouvier Sanjana Auditto Frédéric Brunel Charlotte Jeanneau Michel Camplo Michelle Sergent Imad About Jean-Michel Bolla Jean-Manuel Raimundo |
| author_sort | Serena Carrara |
| collection | DOAJ |
| description | Prosthetic implants are widely used in dentistry and orthopedics and, as a result, infections can occur which cause their removal. Therefore, it is essential to propose methods of eradicating the bacteria that remain on the prosthesis during treatment. For this purpose, it is necessary to develop surfaces whose antibacterial activity can be controlled. Herein, we designed innovative and smart phosphonium self-assembled monolayer (SAM) interfaces that can be electrically activated on demand for controlling bacterial contaminations on solid surfaces. Upon electroactivation with a low potential (0.2 V for 60 min., conditions determined through a <i>DOE</i>), a successful stamping out of Gram-positive and Gram-negative bacterial strains was obtained with SAM-modified titanium surfaces, effectively killing 95% of <i>Staphylococcus aureus</i> and 90% <i>Klebsiella</i><i>pneumoniae</i>. More importantly, no toxicity towards eukaryotic cells was observed which further enhances the biocompatible character of these novel surfaces for further implementation. |
| first_indexed | 2024-03-09T21:43:45Z |
| format | Article |
| id | doaj.art-111f2a4e44104292904bb3430acbeef4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:43:45Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-111f2a4e44104292904bb3430acbeef42023-11-23T20:21:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01234218310.3390/ijms23042183Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on DemandSerena Carrara0Florent Rouvier1Sanjana Auditto2Frédéric Brunel3Charlotte Jeanneau4Michel Camplo5Michelle Sergent6Imad About7Jean-Michel Bolla8Jean-Manuel Raimundo9Aix-Marseille Université, CNRS, CINAM, 13288 Marseille, FranceAix-Marseille Université, INSERM, SSA, IRBA, MCT, 13005 Marseille, FranceAix-Marseille Université, CNRS, CINAM, 13288 Marseille, FranceAix-Marseille Université, CNRS, CINAM, 13288 Marseille, FranceAix-Marseille Université, CNRS, ISM, Inst Movement Sci, 13385 Marseille, FranceAix-Marseille Université, CNRS, CINAM, 13288 Marseille, FranceAix-Marseille Université, CNRS, IRD, IMBE, 13397 Marseille, FranceAix-Marseille Université, CNRS, ISM, Inst Movement Sci, 13385 Marseille, FranceAix-Marseille Université, INSERM, SSA, IRBA, MCT, 13005 Marseille, FranceAix-Marseille Université, CNRS, CINAM, 13288 Marseille, FranceProsthetic implants are widely used in dentistry and orthopedics and, as a result, infections can occur which cause their removal. Therefore, it is essential to propose methods of eradicating the bacteria that remain on the prosthesis during treatment. For this purpose, it is necessary to develop surfaces whose antibacterial activity can be controlled. Herein, we designed innovative and smart phosphonium self-assembled monolayer (SAM) interfaces that can be electrically activated on demand for controlling bacterial contaminations on solid surfaces. Upon electroactivation with a low potential (0.2 V for 60 min., conditions determined through a <i>DOE</i>), a successful stamping out of Gram-positive and Gram-negative bacterial strains was obtained with SAM-modified titanium surfaces, effectively killing 95% of <i>Staphylococcus aureus</i> and 90% <i>Klebsiella</i><i>pneumoniae</i>. More importantly, no toxicity towards eukaryotic cells was observed which further enhances the biocompatible character of these novel surfaces for further implementation.https://www.mdpi.com/1422-0067/23/4/2183phosphoniumsself-assembled monolayersbiocidal effectelectroactivationresponsive surfaces |
| spellingShingle | Serena Carrara Florent Rouvier Sanjana Auditto Frédéric Brunel Charlotte Jeanneau Michel Camplo Michelle Sergent Imad About Jean-Michel Bolla Jean-Manuel Raimundo Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand International Journal of Molecular Sciences phosphoniums self-assembled monolayers biocidal effect electroactivation responsive surfaces |
| title | Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand |
| title_full | Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand |
| title_fullStr | Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand |
| title_full_unstemmed | Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand |
| title_short | Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand |
| title_sort | nanoarchitectonics of electrically activable phosphonium self assembled monolayers to efficiently kill and tackle bacterial infections on demand |
| topic | phosphoniums self-assembled monolayers biocidal effect electroactivation responsive surfaces |
| url | https://www.mdpi.com/1422-0067/23/4/2183 |
| work_keys_str_mv | AT serenacarrara nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT florentrouvier nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT sanjanaauditto nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT fredericbrunel nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT charlottejeanneau nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT michelcamplo nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT michellesergent nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT imadabout nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT jeanmichelbolla nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand AT jeanmanuelraimundo nanoarchitectonicsofelectricallyactivablephosphoniumselfassembledmonolayerstoefficientlykillandtacklebacterialinfectionsondemand |