Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic Biology
Although the synergistic effect of traditional therapies combined with tumor targeting or immunotherapy can significantly reduce mortality, cancer remains the leading cause of disease related death to date. Limited clinical response rate, drug resistance and off-target effects, to a large extent, im...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.845346/full |
| _version_ | 1811311706097319936 |
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| author | Yawei Bao Yong Cheng Wei Liu Wenguang Luo Peijie Zhou Dong Qian |
| author_facet | Yawei Bao Yong Cheng Wei Liu Wenguang Luo Peijie Zhou Dong Qian |
| author_sort | Yawei Bao |
| collection | DOAJ |
| description | Although the synergistic effect of traditional therapies combined with tumor targeting or immunotherapy can significantly reduce mortality, cancer remains the leading cause of disease related death to date. Limited clinical response rate, drug resistance and off-target effects, to a large extent, impede the ceilings of clinical efficiency. To get out from the dilemmas mentioned, bacterial therapy with a history of more than 150 years regained great concern in recent years. The rise of biological engineering and chemical modification strategies are able to optimize tumor bacterial therapy in highest measure, and meanwhile avoid its inherent drawbacks toward clinical application such as bacteriotoxic effects, weak controllability, and low security. Here, we give an overview of recent studies with regard to bacteria-mediated therapies combined with chemotherapy, radiotherapy, and immunotherapy. And more than that, we review the bacterial detoxification and targeting strategies via biological reprogramming or chemical modification, their applications, and clinical transformation prospects. |
| first_indexed | 2024-04-13T10:23:37Z |
| format | Article |
| id | doaj.art-111f97fa8a1c4673b0e45b2140105f8b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T10:23:37Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-111f97fa8a1c4673b0e45b2140105f8b2022-12-22T02:50:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.845346845346Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic BiologyYawei BaoYong ChengWei LiuWenguang LuoPeijie ZhouDong QianAlthough the synergistic effect of traditional therapies combined with tumor targeting or immunotherapy can significantly reduce mortality, cancer remains the leading cause of disease related death to date. Limited clinical response rate, drug resistance and off-target effects, to a large extent, impede the ceilings of clinical efficiency. To get out from the dilemmas mentioned, bacterial therapy with a history of more than 150 years regained great concern in recent years. The rise of biological engineering and chemical modification strategies are able to optimize tumor bacterial therapy in highest measure, and meanwhile avoid its inherent drawbacks toward clinical application such as bacteriotoxic effects, weak controllability, and low security. Here, we give an overview of recent studies with regard to bacteria-mediated therapies combined with chemotherapy, radiotherapy, and immunotherapy. And more than that, we review the bacterial detoxification and targeting strategies via biological reprogramming or chemical modification, their applications, and clinical transformation prospects.https://www.frontiersin.org/articles/10.3389/fonc.2022.845346/fullcancer treatmentimmunotherapybacterial therapychemical modificationsynthetic biology |
| spellingShingle | Yawei Bao Yong Cheng Wei Liu Wenguang Luo Peijie Zhou Dong Qian Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic Biology Frontiers in Oncology cancer treatment immunotherapy bacterial therapy chemical modification synthetic biology |
| title | Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic Biology |
| title_full | Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic Biology |
| title_fullStr | Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic Biology |
| title_full_unstemmed | Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic Biology |
| title_short | Bacteria−Based Synergistic Therapy in the Backdrop of Synthetic Biology |
| title_sort | bacteria based synergistic therapy in the backdrop of synthetic biology |
| topic | cancer treatment immunotherapy bacterial therapy chemical modification synthetic biology |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.845346/full |
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