The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer
<i>Background and objectives:</i> To identify the risk factors for para-aortic lymph node metastases in cases with presumed early stage ovarian cancer. <i>Materials and methods</i>: Between 2014 and 2019, 48 patients with apparent early stage ovarian cancer were submitted to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/3/108 |
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| author | Nicolae Bacalbasa Irina Balescu Mihaela Vilcu Simona Dima Camelia Diaconu Laura Iliescu Alexandru Filipescu Mihai Dimitriu Iulian Brezean |
| author_facet | Nicolae Bacalbasa Irina Balescu Mihaela Vilcu Simona Dima Camelia Diaconu Laura Iliescu Alexandru Filipescu Mihai Dimitriu Iulian Brezean |
| author_sort | Nicolae Bacalbasa |
| collection | DOAJ |
| description | <i>Background and objectives:</i> To identify the risk factors for para-aortic lymph node metastases in cases with presumed early stage ovarian cancer. <i>Materials and methods</i>: Between 2014 and 2019, 48 patients with apparent early stage ovarian cancer were submitted to surgery. In all cases, pelvic and para-aortic lymph node dissection was performed for staging purposes. <i>Results</i>: Among the 48 cases we identified nine cases with positive pelvic lymph nodes and 11 cases with positive para-aortic lymph nodes. The positivity of the retrieved lymph nodes was significantly correlated with the histopathological subtype represented by serous histology (<i>p = </i>0.02), as well as with the degree of differentiation (<i>p = </i>0.004). <i>Conclusion</i>: Patients with serous ovarian carcinomas in association with a poorer degree of differentiation are at risk of associated lymph node metastases even in presumed early stages of the disease. Therefore, lymph node dissection should be performed in such cases in order to provide adequate staging and tailoring of further treatment. |
| first_indexed | 2024-03-12T09:25:58Z |
| format | Article |
| id | doaj.art-111fd80e13394ce799459f4f9b7e5f6a |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:25:58Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-111fd80e13394ce799459f4f9b7e5f6a2023-09-02T14:12:38ZengMDPI AGMedicina1010-660X2020-03-0156310810.3390/medicina56030108medicina56030108The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian CancerNicolae Bacalbasa0Irina Balescu1Mihaela Vilcu2Simona Dima3Camelia Diaconu4Laura Iliescu5Alexandru Filipescu6Mihai Dimitriu7Iulian Brezean8“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Visceral Surgery, Center of Excellence in Translational Medicine, “Fundeni” Clinical Institute, 022328 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania<i>Background and objectives:</i> To identify the risk factors for para-aortic lymph node metastases in cases with presumed early stage ovarian cancer. <i>Materials and methods</i>: Between 2014 and 2019, 48 patients with apparent early stage ovarian cancer were submitted to surgery. In all cases, pelvic and para-aortic lymph node dissection was performed for staging purposes. <i>Results</i>: Among the 48 cases we identified nine cases with positive pelvic lymph nodes and 11 cases with positive para-aortic lymph nodes. The positivity of the retrieved lymph nodes was significantly correlated with the histopathological subtype represented by serous histology (<i>p = </i>0.02), as well as with the degree of differentiation (<i>p = </i>0.004). <i>Conclusion</i>: Patients with serous ovarian carcinomas in association with a poorer degree of differentiation are at risk of associated lymph node metastases even in presumed early stages of the disease. Therefore, lymph node dissection should be performed in such cases in order to provide adequate staging and tailoring of further treatment.https://www.mdpi.com/1010-660X/56/3/108early stageovarian cancerpara-aortic lymph node metastases |
| spellingShingle | Nicolae Bacalbasa Irina Balescu Mihaela Vilcu Simona Dima Camelia Diaconu Laura Iliescu Alexandru Filipescu Mihai Dimitriu Iulian Brezean The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer Medicina early stage ovarian cancer para-aortic lymph node metastases |
| title | The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer |
| title_full | The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer |
| title_fullStr | The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer |
| title_full_unstemmed | The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer |
| title_short | The Risk of Para-Aortic Lymph Node Metastases in Apparent Early Stage Ovarian Cancer |
| title_sort | risk of para aortic lymph node metastases in apparent early stage ovarian cancer |
| topic | early stage ovarian cancer para-aortic lymph node metastases |
| url | https://www.mdpi.com/1010-660X/56/3/108 |
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