Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes

Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes

Abstract Background Temporal lobe epilepsy (TLE) is a chronic neurological disease, in which about 30% of patients cannot be treated adequately with anti-epileptic drugs. Brain inflammation and remodeling of the extracellular matrix (ECM) seem to play a major role in TLE. Matrix metalloproteinases (...

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Bibliographic Details
Main Authors: Anatoly Korotkov, Diede W. M. Broekaart, Jackelien van Scheppingen, Jasper J. Anink, Johannes C. Baayen, Sander Idema, Jan A. Gorter, Eleonora Aronica, Erwin A. van Vliet
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Neuroinflammation
Subjects:
Epileptogenesis
Temporal lobe epilepsy
Extracellular matrix
MiRNA-155
MMP3
Online Access:http://link.springer.com/article/10.1186/s12974-018-1245-y

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