Brief communication: β-cell function influences dopamine receptor availability.
We aim to identify physiologic regulators of dopamine (DA) signaling in obesity but previously did not find a compelling relationship with insulin sensitivity measured by oral-minimal model (OMM) and DA subtype 2 and 3 receptor (D2/3R) binding potential (BPND). Reduced disposition index (DI), a β-ce...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0212738 |
| _version_ | 1818403790659780608 |
|---|---|
| author | Julia P Dunn Naji N Abumrad Bruce W Patterson Robert M Kessler Robyn A Tamboli |
| author_facet | Julia P Dunn Naji N Abumrad Bruce W Patterson Robert M Kessler Robyn A Tamboli |
| author_sort | Julia P Dunn |
| collection | DOAJ |
| description | We aim to identify physiologic regulators of dopamine (DA) signaling in obesity but previously did not find a compelling relationship with insulin sensitivity measured by oral-minimal model (OMM) and DA subtype 2 and 3 receptor (D2/3R) binding potential (BPND). Reduced disposition index (DI), a β-cell function metric that can also be calculated by OMM, was shown to predict a negative reward behavior that occurs in states of lower endogenous DA. We hypothesized that reduced DI would occur with higher D2/3R BPND, reflecting lower endogenous DA. Participants completed PET scanning, with a displaceable radioligand to measure D2/3R BPND, and a 5-hour oral glucose tolerance test to measure DI by OMM. We studied 26 age-similar females without (n = 8) and with obesity (n = 18) (22 vs 39 kg/m2). Reduced DI predicted increased striatal D2/3R BPND independent of BMI. By accounting for β-cell function, we were able to determine that the state of insulin and glucose metabolism is pertinent to striatal D2/3R BPND in obesity. Clinical Trial Registration Number: NCT00802204. |
| first_indexed | 2024-12-14T08:29:51Z |
| format | Article |
| id | doaj.art-1120a81453934a88af281e7e1173a7da |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:29:51Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1120a81453934a88af281e7e1173a7da2022-12-21T23:09:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01143e021273810.1371/journal.pone.0212738Brief communication: β-cell function influences dopamine receptor availability.Julia P DunnNaji N AbumradBruce W PattersonRobert M KesslerRobyn A TamboliWe aim to identify physiologic regulators of dopamine (DA) signaling in obesity but previously did not find a compelling relationship with insulin sensitivity measured by oral-minimal model (OMM) and DA subtype 2 and 3 receptor (D2/3R) binding potential (BPND). Reduced disposition index (DI), a β-cell function metric that can also be calculated by OMM, was shown to predict a negative reward behavior that occurs in states of lower endogenous DA. We hypothesized that reduced DI would occur with higher D2/3R BPND, reflecting lower endogenous DA. Participants completed PET scanning, with a displaceable radioligand to measure D2/3R BPND, and a 5-hour oral glucose tolerance test to measure DI by OMM. We studied 26 age-similar females without (n = 8) and with obesity (n = 18) (22 vs 39 kg/m2). Reduced DI predicted increased striatal D2/3R BPND independent of BMI. By accounting for β-cell function, we were able to determine that the state of insulin and glucose metabolism is pertinent to striatal D2/3R BPND in obesity. Clinical Trial Registration Number: NCT00802204.https://doi.org/10.1371/journal.pone.0212738 |
| spellingShingle | Julia P Dunn Naji N Abumrad Bruce W Patterson Robert M Kessler Robyn A Tamboli Brief communication: β-cell function influences dopamine receptor availability. PLoS ONE |
| title | Brief communication: β-cell function influences dopamine receptor availability. |
| title_full | Brief communication: β-cell function influences dopamine receptor availability. |
| title_fullStr | Brief communication: β-cell function influences dopamine receptor availability. |
| title_full_unstemmed | Brief communication: β-cell function influences dopamine receptor availability. |
| title_short | Brief communication: β-cell function influences dopamine receptor availability. |
| title_sort | brief communication β cell function influences dopamine receptor availability |
| url | https://doi.org/10.1371/journal.pone.0212738 |
| work_keys_str_mv | AT juliapdunn briefcommunicationbcellfunctioninfluencesdopaminereceptoravailability AT najinabumrad briefcommunicationbcellfunctioninfluencesdopaminereceptoravailability AT brucewpatterson briefcommunicationbcellfunctioninfluencesdopaminereceptoravailability AT robertmkessler briefcommunicationbcellfunctioninfluencesdopaminereceptoravailability AT robynatamboli briefcommunicationbcellfunctioninfluencesdopaminereceptoravailability |