Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review
Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of A...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-05-01
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| Series: | Journal of Advanced Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123218300122 |
| _version_ | 1818030971961737216 |
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| author | Undurti N. Das |
| author_facet | Undurti N. Das |
| author_sort | Undurti N. Das |
| collection | DOAJ |
| description | Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of AA in the regulation of blood pressure and its ability to prevent both type 1 and type 2 diabetes mellitus seems to be interesting. Studies showed that AA and its metabolites especially, lipoxin A4 (LXA4) and epoxyeicosatrienoic acids (EETs), potent anti-inflammatory metabolites, have a crucial role in the pathobiology of hypertension and diabetes mellitus. AA, LXA4 and EETs regulate smooth muscle function and proliferation, voltage gated ion channels, cell membrane fluidity, membrane receptors, G-coupled receptors, PPARs, free radical generation, nitric oxide formation, inflammation, and immune responses that, in turn, participate in the regulation blood pressure and pathogenesis of diabetes mellitus. In this review, role of AA and its metabolites LXA4 and EETs in the pathobiology of hypertension, pre-eclampsia and diabetes mellitus are discussed. Based on several lines of evidences, it is proposed that a combination of aspirin and AA could be of benefit in the prevention and management of hypertension, pre-eclampsia and diabetes mellitus. Keywords: Arachidonic acid, Lipoxin A4, Hypertension, Pre-eclampsia, Diabetes mellitus, Inflammation, Cytokines, Free radicals, Nitric oxide |
| first_indexed | 2024-12-10T05:44:04Z |
| format | Article |
| id | doaj.art-1123aa71fcf645eba1b099957c27ca81 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-12-10T05:44:04Z |
| publishDate | 2018-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-1123aa71fcf645eba1b099957c27ca812022-12-22T02:00:13ZengElsevierJournal of Advanced Research2090-12322018-05-01114355Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A reviewUndurti N. Das0UND Life Sciences, 2221 NW 5th St, Battle Ground, WA 98604, USA; BioScience Research Centre, GVP College of Engineering, Visakhapatnam 530 048, IndiaArachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of AA in the regulation of blood pressure and its ability to prevent both type 1 and type 2 diabetes mellitus seems to be interesting. Studies showed that AA and its metabolites especially, lipoxin A4 (LXA4) and epoxyeicosatrienoic acids (EETs), potent anti-inflammatory metabolites, have a crucial role in the pathobiology of hypertension and diabetes mellitus. AA, LXA4 and EETs regulate smooth muscle function and proliferation, voltage gated ion channels, cell membrane fluidity, membrane receptors, G-coupled receptors, PPARs, free radical generation, nitric oxide formation, inflammation, and immune responses that, in turn, participate in the regulation blood pressure and pathogenesis of diabetes mellitus. In this review, role of AA and its metabolites LXA4 and EETs in the pathobiology of hypertension, pre-eclampsia and diabetes mellitus are discussed. Based on several lines of evidences, it is proposed that a combination of aspirin and AA could be of benefit in the prevention and management of hypertension, pre-eclampsia and diabetes mellitus. Keywords: Arachidonic acid, Lipoxin A4, Hypertension, Pre-eclampsia, Diabetes mellitus, Inflammation, Cytokines, Free radicals, Nitric oxidehttp://www.sciencedirect.com/science/article/pii/S2090123218300122 |
| spellingShingle | Undurti N. Das Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review Journal of Advanced Research |
| title | Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review |
| title_full | Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review |
| title_fullStr | Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review |
| title_full_unstemmed | Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review |
| title_short | Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review |
| title_sort | arachidonic acid in health and disease with focus on hypertension and diabetes mellitus a review |
| url | http://www.sciencedirect.com/science/article/pii/S2090123218300122 |
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