Towards Novel Geneless Approaches for Therapeutic Angiogenesis
Cardiovascular diseases are the leading cause of mortality worldwide. Such a widespread diffusion makes the conditions affecting the heart and blood vessels a primary medical and economic burden. It, therefore, becomes mandatory to identify effective treatments that can alleviate this global problem...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.616189/full |
| _version_ | 1819298459226734592 |
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| author | Francesco Moccia Maria Rosa Antognazza Francesco Lodola Francesco Lodola |
| author_facet | Francesco Moccia Maria Rosa Antognazza Francesco Lodola Francesco Lodola |
| author_sort | Francesco Moccia |
| collection | DOAJ |
| description | Cardiovascular diseases are the leading cause of mortality worldwide. Such a widespread diffusion makes the conditions affecting the heart and blood vessels a primary medical and economic burden. It, therefore, becomes mandatory to identify effective treatments that can alleviate this global problem. Among the different solutions brought to the attention of the medical-scientific community, therapeutic angiogenesis is one of the most promising. However, this approach, which aims to treat cardiovascular diseases by generating new blood vessels in ischemic tissues, has so far led to inadequate results due to several issues. In this perspective, we will discuss cutting-edge approaches and future perspectives to alleviate the potentially lethal impact of cardiovascular diseases. We will focus on the consolidated role of resident endothelial progenitor cells, particularly endothelial colony forming cells, as suitable candidates for cell-based therapy demonstrating the importance of targeting intracellular Ca2+ signaling to boost their regenerative outcome. Moreover, we will elucidate the advantages of physical stimuli over traditional approaches. In particular, we will critically discuss recent results obtained by using optical stimulation, as a novel strategy to drive endothelial colony forming cells fate and its potential in the treatment of cardiovascular diseases. |
| first_indexed | 2024-12-24T05:30:14Z |
| format | Article |
| id | doaj.art-11254a8f14514badb5bb64e654891951 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-24T05:30:14Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-11254a8f14514badb5bb64e6548919512022-12-21T17:13:11ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-01-011110.3389/fphys.2020.616189616189Towards Novel Geneless Approaches for Therapeutic AngiogenesisFrancesco Moccia0Maria Rosa Antognazza1Francesco Lodola2Francesco Lodola3Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, ItalyCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Milan, ItalyCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, ItalyCardiovascular diseases are the leading cause of mortality worldwide. Such a widespread diffusion makes the conditions affecting the heart and blood vessels a primary medical and economic burden. It, therefore, becomes mandatory to identify effective treatments that can alleviate this global problem. Among the different solutions brought to the attention of the medical-scientific community, therapeutic angiogenesis is one of the most promising. However, this approach, which aims to treat cardiovascular diseases by generating new blood vessels in ischemic tissues, has so far led to inadequate results due to several issues. In this perspective, we will discuss cutting-edge approaches and future perspectives to alleviate the potentially lethal impact of cardiovascular diseases. We will focus on the consolidated role of resident endothelial progenitor cells, particularly endothelial colony forming cells, as suitable candidates for cell-based therapy demonstrating the importance of targeting intracellular Ca2+ signaling to boost their regenerative outcome. Moreover, we will elucidate the advantages of physical stimuli over traditional approaches. In particular, we will critically discuss recent results obtained by using optical stimulation, as a novel strategy to drive endothelial colony forming cells fate and its potential in the treatment of cardiovascular diseases.https://www.frontiersin.org/articles/10.3389/fphys.2020.616189/fullcardiovascular diseasetherapeutic angiogenesisendothelial colony forming cellsintracellular Ca2+ signalingtransient receptor potential vanilloid 1cell fate |
| spellingShingle | Francesco Moccia Maria Rosa Antognazza Francesco Lodola Francesco Lodola Towards Novel Geneless Approaches for Therapeutic Angiogenesis Frontiers in Physiology cardiovascular disease therapeutic angiogenesis endothelial colony forming cells intracellular Ca2+ signaling transient receptor potential vanilloid 1 cell fate |
| title | Towards Novel Geneless Approaches for Therapeutic Angiogenesis |
| title_full | Towards Novel Geneless Approaches for Therapeutic Angiogenesis |
| title_fullStr | Towards Novel Geneless Approaches for Therapeutic Angiogenesis |
| title_full_unstemmed | Towards Novel Geneless Approaches for Therapeutic Angiogenesis |
| title_short | Towards Novel Geneless Approaches for Therapeutic Angiogenesis |
| title_sort | towards novel geneless approaches for therapeutic angiogenesis |
| topic | cardiovascular disease therapeutic angiogenesis endothelial colony forming cells intracellular Ca2+ signaling transient receptor potential vanilloid 1 cell fate |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2020.616189/full |
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