Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation
The 4th World Congress of Electroporation (Copenhagen, 9–13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harness electric fields to produce therapeutically useful effects on cancers and represent a valuable option for a v...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/13/3340 |
| _version_ | 1797591945355198464 |
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| author | Luca G. Campana Adil Daud Francesco Lancellotti Julio P. Arroyo Rafael V. Davalos Claudia Di Prata Julie Gehl |
| author_facet | Luca G. Campana Adil Daud Francesco Lancellotti Julio P. Arroyo Rafael V. Davalos Claudia Di Prata Julie Gehl |
| author_sort | Luca G. Campana |
| collection | DOAJ |
| description | The 4th World Congress of Electroporation (Copenhagen, 9–13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harness electric fields to produce therapeutically useful effects on cancers and represent a valuable option for a variety of patients. As such, irreversible electroporation (IRE), gene electrotransfer (GET), electrochemotherapy (ECT), calcium electroporation (Ca-EP), and tumour-treating fields (TTF) are on the rise. Still, their full therapeutic potential remains underappreciated, and the field faces fragmentation, as shown by parallel maturation and differences in the stages of development and regulatory approval worldwide. This narrative review provides a glimpse of PEF-based techniques, including key mechanisms, clinical indications, and advances in therapy; finally, it offers insights into current research directions. By highlighting a common ground, the authors aim to break silos, strengthen cross-functional collaboration, and pave the way to novel possibilities for intervention. Intriguingly, beyond their peculiar mechanism of action, PEF-based therapies share technical interconnections and multifaceted biological effects (e.g., vascular, immunological) worth exploiting in combinatorial strategies. |
| first_indexed | 2024-03-11T01:45:47Z |
| format | Article |
| id | doaj.art-1125c6fba16a42969531a95e440e8cbc |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:45:47Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1125c6fba16a42969531a95e440e8cbc2023-11-18T16:15:35ZengMDPI AGCancers2072-66942023-06-011513334010.3390/cancers15133340Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of ElectroporationLuca G. Campana0Adil Daud1Francesco Lancellotti2Julio P. Arroyo3Rafael V. Davalos4Claudia Di Prata5Julie Gehl6Department of Surgery, Manchester University NHS Foundation Trust, Oxford Rd., Manchester M13 9WL, UKDepartment of Medicine, University of California, 550 16 Street, San Francisco, CA 94158, USADepartment of Surgery, Manchester University NHS Foundation Trust, Oxford Rd., Manchester M13 9WL, UKDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA 24061, USADepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA 24061, USADepartment of Surgery, San Martino Hospital, 32100 Belluno, ItalyDepartment of Clinical Oncology and Palliative Care, Zealand University Hospital, 4000 Roskilde, DenmarkThe 4th World Congress of Electroporation (Copenhagen, 9–13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harness electric fields to produce therapeutically useful effects on cancers and represent a valuable option for a variety of patients. As such, irreversible electroporation (IRE), gene electrotransfer (GET), electrochemotherapy (ECT), calcium electroporation (Ca-EP), and tumour-treating fields (TTF) are on the rise. Still, their full therapeutic potential remains underappreciated, and the field faces fragmentation, as shown by parallel maturation and differences in the stages of development and regulatory approval worldwide. This narrative review provides a glimpse of PEF-based techniques, including key mechanisms, clinical indications, and advances in therapy; finally, it offers insights into current research directions. By highlighting a common ground, the authors aim to break silos, strengthen cross-functional collaboration, and pave the way to novel possibilities for intervention. Intriguingly, beyond their peculiar mechanism of action, PEF-based therapies share technical interconnections and multifaceted biological effects (e.g., vascular, immunological) worth exploiting in combinatorial strategies.https://www.mdpi.com/2072-6694/15/13/3340cancerelectroporationirreversible electroporationgene electrotransferelectrochemotherapytumour-treating fields |
| spellingShingle | Luca G. Campana Adil Daud Francesco Lancellotti Julio P. Arroyo Rafael V. Davalos Claudia Di Prata Julie Gehl Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation Cancers cancer electroporation irreversible electroporation gene electrotransfer electrochemotherapy tumour-treating fields |
| title | Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation |
| title_full | Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation |
| title_fullStr | Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation |
| title_full_unstemmed | Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation |
| title_short | Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation |
| title_sort | pulsed electric fields in oncology a snapshot of current clinical practices and research directions from the 4th world congress of electroporation |
| topic | cancer electroporation irreversible electroporation gene electrotransfer electrochemotherapy tumour-treating fields |
| url | https://www.mdpi.com/2072-6694/15/13/3340 |
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