Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke
The blood–brain barrier (BBB) acts as a physical and biochemical barrier that plays a fundamental role in regulating the blood-to-brain influx of endogenous and exogenous components and maintaining the homeostatic microenvironment of the central nervous system (CNS). Acute stroke leads to BBB disrup...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.856372/full |
| _version_ | 1818284744766390272 |
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| author | Xiaodong Ye Guini Song Shanshan Huang Qiming Liang Yongkang Fang Lifei Lian Suiqiang Zhu |
| author_facet | Xiaodong Ye Guini Song Shanshan Huang Qiming Liang Yongkang Fang Lifei Lian Suiqiang Zhu |
| author_sort | Xiaodong Ye |
| collection | DOAJ |
| description | The blood–brain barrier (BBB) acts as a physical and biochemical barrier that plays a fundamental role in regulating the blood-to-brain influx of endogenous and exogenous components and maintaining the homeostatic microenvironment of the central nervous system (CNS). Acute stroke leads to BBB disruption, blood substances extravasation into the brain parenchyma, and the consequence of brain edema formation with neurological impairment afterward. Caspase-1, one of the evolutionary conserved families of cysteine proteases, which is upregulated in acute stroke, mainly mediates pyroptosis and compromises BBB integrity via lytic cellular death and inflammatory cytokines release. Nowadays, targeting caspase-1 has been proven to be effective in decreasing the occurrence of hemorrhagic transformation (HT) and in attenuating brain edema and secondary damages during acute stroke. However, the underlying interactions among caspase-1, BBB, and stroke still remain ill-defined. Hence, in this review, we are concerned about the roles of caspase-1 activation and its associated mechanisms in stroke-induced BBB damage, aiming at providing insights into the significance of caspase-1 inhibition on stroke treatment in the near future. |
| first_indexed | 2024-12-13T00:57:40Z |
| format | Article |
| id | doaj.art-1127ac4b915e4d679a3c9e92b3dbb40a |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-13T00:57:40Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-1127ac4b915e4d679a3c9e92b3dbb40a2022-12-22T00:04:45ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-03-011510.3389/fnmol.2022.856372856372Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute StrokeXiaodong YeGuini SongShanshan HuangQiming LiangYongkang FangLifei LianSuiqiang ZhuThe blood–brain barrier (BBB) acts as a physical and biochemical barrier that plays a fundamental role in regulating the blood-to-brain influx of endogenous and exogenous components and maintaining the homeostatic microenvironment of the central nervous system (CNS). Acute stroke leads to BBB disruption, blood substances extravasation into the brain parenchyma, and the consequence of brain edema formation with neurological impairment afterward. Caspase-1, one of the evolutionary conserved families of cysteine proteases, which is upregulated in acute stroke, mainly mediates pyroptosis and compromises BBB integrity via lytic cellular death and inflammatory cytokines release. Nowadays, targeting caspase-1 has been proven to be effective in decreasing the occurrence of hemorrhagic transformation (HT) and in attenuating brain edema and secondary damages during acute stroke. However, the underlying interactions among caspase-1, BBB, and stroke still remain ill-defined. Hence, in this review, we are concerned about the roles of caspase-1 activation and its associated mechanisms in stroke-induced BBB damage, aiming at providing insights into the significance of caspase-1 inhibition on stroke treatment in the near future.https://www.frontiersin.org/articles/10.3389/fnmol.2022.856372/fullcaspase-1ischemic strokehemorrhagic strokeblood-brain barrierpyroptosiscerebral edema |
| spellingShingle | Xiaodong Ye Guini Song Shanshan Huang Qiming Liang Yongkang Fang Lifei Lian Suiqiang Zhu Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke Frontiers in Molecular Neuroscience caspase-1 ischemic stroke hemorrhagic stroke blood-brain barrier pyroptosis cerebral edema |
| title | Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke |
| title_full | Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke |
| title_fullStr | Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke |
| title_full_unstemmed | Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke |
| title_short | Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke |
| title_sort | caspase 1 a promising target for preserving blood brain barrier integrity in acute stroke |
| topic | caspase-1 ischemic stroke hemorrhagic stroke blood-brain barrier pyroptosis cerebral edema |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.856372/full |
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