The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review
Background: Schizophrenia is a severe mental disorder characterized by positive, negative, affective, and cognitive symptoms. Affective symptoms in patients with schizophrenia have traditionally been overlooked or even neglected because they are not considered as fundamental as positive and negative...
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MDPI AG
2024-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/3/225 |
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| author | Andrea Fiorillo Gaia Sampogna Umberto Albert Emi Bondi Serafino De Giorgi Andrea Fagiolini Maurizio Pompili Gianluca Serafini Umberto Volpe Antonio Vita |
| author_facet | Andrea Fiorillo Gaia Sampogna Umberto Albert Emi Bondi Serafino De Giorgi Andrea Fagiolini Maurizio Pompili Gianluca Serafini Umberto Volpe Antonio Vita |
| author_sort | Andrea Fiorillo |
| collection | DOAJ |
| description | Background: Schizophrenia is a severe mental disorder characterized by positive, negative, affective, and cognitive symptoms. Affective symptoms in patients with schizophrenia have traditionally been overlooked or even neglected because they are not considered as fundamental as positive and negative symptoms in the choice of medication. Methods: This paper aims to systematically evaluate the efficacy and safety of lurasidone in the treatment of depressive symptoms of schizophrenia. Results: Lurasidone appears to be particularly effective on the depressive symptomatology of schizophrenia while also alleviating the positive and negative symptoms associated with the illness. Conclusions: The efficacy of lurasidone in treating patients with first-episode psychosis who present with predominant depressive symptoms suggests that this medication may be a valuable treatment option not only for established cases of schizophrenia but also for individuals in the early stages of the illness. The good tolerability of lurasidone is an important factor that may positively influence treatment decisions. |
| first_indexed | 2024-04-24T18:28:42Z |
| format | Article |
| id | doaj.art-112bb0c3ac2240bd8d831f8bd64b8de3 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-24T18:28:42Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-112bb0c3ac2240bd8d831f8bd64b8de32024-03-27T13:28:41ZengMDPI AGBrain Sciences2076-34252024-02-0114322510.3390/brainsci14030225The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A ReviewAndrea Fiorillo0Gaia Sampogna1Umberto Albert2Emi Bondi3Serafino De Giorgi4Andrea Fagiolini5Maurizio Pompili6Gianluca Serafini7Umberto Volpe8Antonio Vita9Department of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, ItalyDepartment of Mental Health and Addictions, ASST Papa Giovanni XXIII, 24121 Bergamo, ItalyDepartment of Mental Health, ASL Lecce, 73100 Lecce, ItalyDivision of Psychiatry, University of Siena, 53100 Siena, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs, Sant’Andrea Hospital, Sapienza University of Rome, Via di Grottarossa, 1035, 00189 Rome, ItalySection of Psychiatry, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16131 Genoa, ItalyClinical Psychiatry Unit, Department of Clinical Neurosciences, Università Politecnica delle Marche, 60126 Ancona, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, ItalyBackground: Schizophrenia is a severe mental disorder characterized by positive, negative, affective, and cognitive symptoms. Affective symptoms in patients with schizophrenia have traditionally been overlooked or even neglected because they are not considered as fundamental as positive and negative symptoms in the choice of medication. Methods: This paper aims to systematically evaluate the efficacy and safety of lurasidone in the treatment of depressive symptoms of schizophrenia. Results: Lurasidone appears to be particularly effective on the depressive symptomatology of schizophrenia while also alleviating the positive and negative symptoms associated with the illness. Conclusions: The efficacy of lurasidone in treating patients with first-episode psychosis who present with predominant depressive symptoms suggests that this medication may be a valuable treatment option not only for established cases of schizophrenia but also for individuals in the early stages of the illness. The good tolerability of lurasidone is an important factor that may positively influence treatment decisions.https://www.mdpi.com/2076-3425/14/3/225schizophreniapersonalized treatmentdepressive symptomsantipsychoticlurasidone |
| spellingShingle | Andrea Fiorillo Gaia Sampogna Umberto Albert Emi Bondi Serafino De Giorgi Andrea Fagiolini Maurizio Pompili Gianluca Serafini Umberto Volpe Antonio Vita The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review Brain Sciences schizophrenia personalized treatment depressive symptoms antipsychotic lurasidone |
| title | The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review |
| title_full | The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review |
| title_fullStr | The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review |
| title_full_unstemmed | The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review |
| title_short | The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review |
| title_sort | role of lurasidone in managing depressive symptoms in people with schizophrenia a review |
| topic | schizophrenia personalized treatment depressive symptoms antipsychotic lurasidone |
| url | https://www.mdpi.com/2076-3425/14/3/225 |
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