EFFECTIVENESS OF POLYCATIONIC NANOPARTICLES OF POLYETHYLENEIMINE-POLYHYDROZIDE-CHITOSAN (PEI-PG-OCHG) AS A VECTOR FOR SMALL INTERFERING RNA, DIRECTED TO SUPPRESS HERPES SIMPLEX TYPE 2 VIRUS REPLICATION

EFFECTIVENESS OF POLYCATIONIC NANOPARTICLES OF POLYETHYLENEIMINE-POLYHYDROZIDE-CHITOSAN (PEI-PG-OCHG) AS A VECTOR FOR SMALL INTERFERING RNA, DIRECTED TO SUPPRESS HERPES SIMPLEX TYPE 2 VIRUS REPLICATION

Aim. Evaluation of an antiviral effect of miRNA in the nanoparticles of a polycationic compound against mRNA of vp16 protein (UL48 gene) of herpes simplex virus type 2 (HSV-2) in vitro. Materials and methods. 50% aqueous solution of polyethyleneimine (BDH, Great Britain), chitosan, containing approx...

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Bibliographic Details
Main Authors: A. S Borisenko, O. A Svitich, G. G Krivtsov, V. F Lavrov, V. S Popova, T. M Parfenova
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2015-06-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
small interfering rna
antiviral effect
herpes simplex virus type 2
polycationic compounds
Online Access:https://microbiol.crie.ru/jour/article/view/14027

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