Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression
Oestrogen receptor beta (ERβ) and epidermal growth factor receptor (EGFR) pathway can synergistically promote the proliferation, invasion, and metastasis of non-small-cell lung cancer (NSCLC) cells. ERβ has five subtypes, and the selective splicing of exon 8 in ERβ5 transcription translational phase...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Autoimmunity |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08916934.2018.1486825 |
| _version_ | 1797684720798007296 |
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| author | Yuquan Bai Wulin Shen Li Zhang Zetian Yang Lecai Xiong Hexiao Tang Jinping Zhao |
| author_facet | Yuquan Bai Wulin Shen Li Zhang Zetian Yang Lecai Xiong Hexiao Tang Jinping Zhao |
| author_sort | Yuquan Bai |
| collection | DOAJ |
| description | Oestrogen receptor beta (ERβ) and epidermal growth factor receptor (EGFR) pathway can synergistically promote the proliferation, invasion, and metastasis of non-small-cell lung cancer (NSCLC) cells. ERβ has five subtypes, and the selective splicing of exon 8 in ERβ5 transcription translational phase makes its biological function different from other subtypes. The following study investigates whether ERβ5 interacts with EGFR pathway in lung cancer. Briefly, we found that the overexpression of ERβ5 and EGFR is associated with poor prognosis and decreased overall survival in NSCLC patients. Furthermore, the effects of ERβ5 and EGFR on cell biological behaviour were investigated in vitro. These results indicated that the combination of ERβ5 and EGF induces cell proliferation and invasion, while the combination of ERβ5 and Gefitinib (EGFR inhibitors, Gef) induces cell apoptosis and promotes cell mitosis in A549 cell line. In addition, the combination of ERβ5 and EGF increases the expression of ERβ5, EGFR, and p-ERK1/2 in lung cancer cells. To sum up, the obtained results suggest that ERβ5 and EGFR synergistically promote the progression of lung cancer by activating MEK/ERK signalling pathway, which provides a theoretical basis for more accurate combined targeted therapy. |
| first_indexed | 2024-03-12T00:34:48Z |
| format | Article |
| id | doaj.art-112c75bf4bac4acf9d28bc853c65d76f |
| institution | Directory Open Access Journal |
| issn | 0891-6934 1607-842X |
| language | English |
| last_indexed | 2024-03-12T00:34:48Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj.art-112c75bf4bac4acf9d28bc853c65d76f2023-09-15T10:01:07ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2018-05-0151415716510.1080/08916934.2018.14868251486825Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progressionYuquan Bai0Wulin Shen1Li Zhang2Zetian Yang3Lecai Xiong4Hexiao Tang5Jinping Zhao6Zhongnan Hospital of Wuhan UniversityZhongnan Hospital of Wuhan UniversityZhongnan Hospital of Wuhan UniversityZhongnan Hospital of Wuhan UniversityZhongnan Hospital of Wuhan UniversityZhongnan Hospital of Wuhan UniversityZhongnan Hospital of Wuhan UniversityOestrogen receptor beta (ERβ) and epidermal growth factor receptor (EGFR) pathway can synergistically promote the proliferation, invasion, and metastasis of non-small-cell lung cancer (NSCLC) cells. ERβ has five subtypes, and the selective splicing of exon 8 in ERβ5 transcription translational phase makes its biological function different from other subtypes. The following study investigates whether ERβ5 interacts with EGFR pathway in lung cancer. Briefly, we found that the overexpression of ERβ5 and EGFR is associated with poor prognosis and decreased overall survival in NSCLC patients. Furthermore, the effects of ERβ5 and EGFR on cell biological behaviour were investigated in vitro. These results indicated that the combination of ERβ5 and EGF induces cell proliferation and invasion, while the combination of ERβ5 and Gefitinib (EGFR inhibitors, Gef) induces cell apoptosis and promotes cell mitosis in A549 cell line. In addition, the combination of ERβ5 and EGF increases the expression of ERβ5, EGFR, and p-ERK1/2 in lung cancer cells. To sum up, the obtained results suggest that ERβ5 and EGFR synergistically promote the progression of lung cancer by activating MEK/ERK signalling pathway, which provides a theoretical basis for more accurate combined targeted therapy.http://dx.doi.org/10.1080/08916934.2018.1486825non-small cell lung cancererβ5egfrgefitiniberk |
| spellingShingle | Yuquan Bai Wulin Shen Li Zhang Zetian Yang Lecai Xiong Hexiao Tang Jinping Zhao Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression Autoimmunity non-small cell lung cancer erβ5 egfr gefitinib erk |
| title | Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression |
| title_full | Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression |
| title_fullStr | Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression |
| title_full_unstemmed | Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression |
| title_short | Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression |
| title_sort | oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression |
| topic | non-small cell lung cancer erβ5 egfr gefitinib erk |
| url | http://dx.doi.org/10.1080/08916934.2018.1486825 |
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