Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome
Nonalcoholic fatty liver disease (NAFLD) is considered a manifestation of metabolic syndrome (MS) and is characterized by the accumulation of triglycerides and a varying degree of hepatic injury, inflammation, and repair. Moreover, peroxisome-proliferator-activated receptors (PPARs) play a critical...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/8939 |
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| author | Agustina Cano-Martínez Rocío Bautista-Pérez Vicente Castrejón-Téllez Elizabeth Carreón-Torres Israel Pérez-Torres Eulises Díaz-Díaz Javier Flores-Estrada Verónica Guarner-Lans María Esther Rubio-Ruíz |
| author_facet | Agustina Cano-Martínez Rocío Bautista-Pérez Vicente Castrejón-Téllez Elizabeth Carreón-Torres Israel Pérez-Torres Eulises Díaz-Díaz Javier Flores-Estrada Verónica Guarner-Lans María Esther Rubio-Ruíz |
| author_sort | Agustina Cano-Martínez |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is considered a manifestation of metabolic syndrome (MS) and is characterized by the accumulation of triglycerides and a varying degree of hepatic injury, inflammation, and repair. Moreover, peroxisome-proliferator-activated receptors (PPARs) play a critical role in the pathophysiological processes in the liver. There is extensive evidence of the beneficial effect of polyphenols such as resveratrol (RSV) and quercetin (QRC) on the treatment of liver pathology; however, the mechanisms underlying their beneficial effects have not been fully elucidated. In this work, we show that the mechanisms underlying the beneficial effects of RSV and QRC against inflammation in liver damage in our MS model are due to the activation of novel pathways which have not been previously described such as the downregulation of the expression of toll-like receptor 4 (TLR4), neutrophil elastase (NE) and purinergic receptor P2Y2. This downregulation leads to a decrease in apoptosis and hepatic fibrosis with no changes in hepatocyte proliferation. In addition, PPAR alpha and gamma expression were altered in MS but their expression was not affected by the treatment with the natural compounds. The improvement of liver damage by the administration of polyphenols was reflected in the normalization of serum transaminase activities. |
| first_indexed | 2024-03-10T08:43:33Z |
| format | Article |
| id | doaj.art-112cc74b36e744e5b84b74068fed1ee6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:43:33Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-112cc74b36e744e5b84b74068fed1ee62023-11-22T08:02:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216893910.3390/ijms22168939Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic SyndromeAgustina Cano-Martínez0Rocío Bautista-Pérez1Vicente Castrejón-Téllez2Elizabeth Carreón-Torres3Israel Pérez-Torres4Eulises Díaz-Díaz5Javier Flores-Estrada6Verónica Guarner-Lans7María Esther Rubio-Ruíz8Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City 14080, MexicoDivisión de Investigación, Hospital Juárez de México, Av. Instituto Politécnico Nacional 5160, Magdalena de las Salinas, Gustavo A. Madero, Mexico City 07760, MexicoDepartment of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoNonalcoholic fatty liver disease (NAFLD) is considered a manifestation of metabolic syndrome (MS) and is characterized by the accumulation of triglycerides and a varying degree of hepatic injury, inflammation, and repair. Moreover, peroxisome-proliferator-activated receptors (PPARs) play a critical role in the pathophysiological processes in the liver. There is extensive evidence of the beneficial effect of polyphenols such as resveratrol (RSV) and quercetin (QRC) on the treatment of liver pathology; however, the mechanisms underlying their beneficial effects have not been fully elucidated. In this work, we show that the mechanisms underlying the beneficial effects of RSV and QRC against inflammation in liver damage in our MS model are due to the activation of novel pathways which have not been previously described such as the downregulation of the expression of toll-like receptor 4 (TLR4), neutrophil elastase (NE) and purinergic receptor P2Y2. This downregulation leads to a decrease in apoptosis and hepatic fibrosis with no changes in hepatocyte proliferation. In addition, PPAR alpha and gamma expression were altered in MS but their expression was not affected by the treatment with the natural compounds. The improvement of liver damage by the administration of polyphenols was reflected in the normalization of serum transaminase activities.https://www.mdpi.com/1422-0067/22/16/8939inflammationliver damagetoll-like receptor 4P2Y2 receptormetabolic syndromeresveratrol |
| spellingShingle | Agustina Cano-Martínez Rocío Bautista-Pérez Vicente Castrejón-Téllez Elizabeth Carreón-Torres Israel Pérez-Torres Eulises Díaz-Díaz Javier Flores-Estrada Verónica Guarner-Lans María Esther Rubio-Ruíz Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome International Journal of Molecular Sciences inflammation liver damage toll-like receptor 4 P2Y2 receptor metabolic syndrome resveratrol |
| title | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome |
| title_full | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome |
| title_fullStr | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome |
| title_full_unstemmed | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome |
| title_short | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome |
| title_sort | resveratrol and quercetin as regulators of inflammatory and purinergic receptors to attenuate liver damage associated to metabolic syndrome |
| topic | inflammation liver damage toll-like receptor 4 P2Y2 receptor metabolic syndrome resveratrol |
| url | https://www.mdpi.com/1422-0067/22/16/8939 |
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