PHD3 inhibits cell proliferation through hydroxylation of PAX2 at proline 9

PHD3 inhibits cell proliferation through hydroxylation of PAX2 at proline 9

The oncoprotein transcription factor paired box 2 (PAX2) is aberrantly expressed in cancers, but the underlying mechanism remains elusive. Prolyl hydroxylase 3 (PHD3) hydroxylates the proline residue of HIFα, mediating HIFα degradation. The von Hippel-Lindau protein (pVHL) is an E3 ligase which med...

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Bibliographic Details
Main Authors: Lun Jie, Wang Yuxin, Gao Qiang, Wang Yu, Zhang Hongwei, Fang Jing
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-04-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
PHD3
PAX2
pVHL
prolyl hydroxylation
cell proliferation
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022043

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