The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans
Fibroblast growth factor receptors (FGFRs) regulate diverse biological processes in eukaryotes. The nematode Caenorhabditis elegans is a good animal model for studying the roles of FGFR signaling and its mechanism of regulation. In this study, we report that KIN-9 is an FGFR homolog in C. elegans th...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2022.866861/full |
| _version_ | 1828325115281014784 |
|---|---|
| author | Avijit Mallick Leo Xu Sakshi Mehta Shane K. B. Taylor Hannah Hosein Bhagwati P. Gupta |
| author_facet | Avijit Mallick Leo Xu Sakshi Mehta Shane K. B. Taylor Hannah Hosein Bhagwati P. Gupta |
| author_sort | Avijit Mallick |
| collection | DOAJ |
| description | Fibroblast growth factor receptors (FGFRs) regulate diverse biological processes in eukaryotes. The nematode Caenorhabditis elegans is a good animal model for studying the roles of FGFR signaling and its mechanism of regulation. In this study, we report that KIN-9 is an FGFR homolog in C. elegans that plays essential roles in aging and stress response maintenance. kin-9 was discovered as a target of miR-246, a microRNA that is positively regulated by the Axin family member pry-1. We found that animals lacking kin-9 function were long-lived and resistant to chemically induced stress. Furthermore, they showed a reduced expression of endoplasmic reticulum unfolded protein response (ER-UPR) pathway genes, suggesting that kin-9 is required to maintain a normal ER-UPR. The analysis of GFP reporter-based expression in transgenic animals revealed that KIN-9 is localized in the intestine. Overall, our findings demonstrate that kin-9 is regulated by miR-246 and may function downstream of pry-1. This study prompts future investigations to understand the mechanism of miRNA-mediated FGFR function in maintaining aging and stress response processes. |
| first_indexed | 2024-04-13T19:17:36Z |
| format | Article |
| id | doaj.art-1130843179c540838c445c42520b747c |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-04-13T19:17:36Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-1130843179c540838c445c42520b747c2022-12-22T02:33:38ZengFrontiers Media S.A.Frontiers in Aging2673-62172022-05-01310.3389/fragi.2022.866861866861The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegansAvijit MallickLeo XuSakshi MehtaShane K. B. TaylorHannah HoseinBhagwati P. GuptaFibroblast growth factor receptors (FGFRs) regulate diverse biological processes in eukaryotes. The nematode Caenorhabditis elegans is a good animal model for studying the roles of FGFR signaling and its mechanism of regulation. In this study, we report that KIN-9 is an FGFR homolog in C. elegans that plays essential roles in aging and stress response maintenance. kin-9 was discovered as a target of miR-246, a microRNA that is positively regulated by the Axin family member pry-1. We found that animals lacking kin-9 function were long-lived and resistant to chemically induced stress. Furthermore, they showed a reduced expression of endoplasmic reticulum unfolded protein response (ER-UPR) pathway genes, suggesting that kin-9 is required to maintain a normal ER-UPR. The analysis of GFP reporter-based expression in transgenic animals revealed that KIN-9 is localized in the intestine. Overall, our findings demonstrate that kin-9 is regulated by miR-246 and may function downstream of pry-1. This study prompts future investigations to understand the mechanism of miRNA-mediated FGFR function in maintaining aging and stress response processes.https://www.frontiersin.org/articles/10.3389/fragi.2022.866861/fullkin-9FGFR4pry-1miR-246agingstress response |
| spellingShingle | Avijit Mallick Leo Xu Sakshi Mehta Shane K. B. Taylor Hannah Hosein Bhagwati P. Gupta The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans Frontiers in Aging kin-9 FGFR4 pry-1 miR-246 aging stress response |
| title | The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans |
| title_full | The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans |
| title_fullStr | The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans |
| title_full_unstemmed | The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans |
| title_short | The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans |
| title_sort | fgfr4 homolog kin 9 regulates lifespan and stress responses in caenorhabditis elegans |
| topic | kin-9 FGFR4 pry-1 miR-246 aging stress response |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2022.866861/full |
| work_keys_str_mv | AT avijitmallick thefgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT leoxu thefgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT sakshimehta thefgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT shanekbtaylor thefgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT hannahhosein thefgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT bhagwatipgupta thefgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT avijitmallick fgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT leoxu fgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT sakshimehta fgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT shanekbtaylor fgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT hannahhosein fgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans AT bhagwatipgupta fgfr4homologkin9regulateslifespanandstressresponsesincaenorhabditiselegans |