Potential use of angiotensin receptor blockers in skin pathologies
Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-07-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_21929_06b00c767ebd88266c0ea5ec31641aef.pdf |
| _version_ | 1797682660748820480 |
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| author | Keshvad Hedayatyanfard Azadeh Khalili Hosein Karim Soren Nooraei Ehsan Khosravi Nazgol Sadat Haddadi Ahmad Reza Dehpour Gholamreza Bayat |
| author_facet | Keshvad Hedayatyanfard Azadeh Khalili Hosein Karim Soren Nooraei Ehsan Khosravi Nazgol Sadat Haddadi Ahmad Reza Dehpour Gholamreza Bayat |
| author_sort | Keshvad Hedayatyanfard |
| collection | DOAJ |
| description | Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT2R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-6. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects. |
| first_indexed | 2024-03-12T00:03:49Z |
| format | Article |
| id | doaj.art-1130e22bf94e45b29eef38083262d813 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-03-12T00:03:49Z |
| publishDate | 2023-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-1130e22bf94e45b29eef38083262d8132023-09-17T06:58:07ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742023-07-0126773273710.22038/ijbms.2023.66563.1460621929Potential use of angiotensin receptor blockers in skin pathologiesKeshvad Hedayatyanfard0Azadeh Khalili1Hosein Karim2Soren Nooraei3Ehsan Khosravi4Nazgol Sadat Haddadi5Ahmad Reza Dehpour6Gholamreza Bayat7Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, IranDepartment of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, IranCardiovascular Research Center, Alborz University of Medical Sciences, Karaj, IranStudent of School of Veterinary Medicine, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, IranDepartment of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Dermatology, University of Massachusetts School of Medicine, Worchester, MA, USADepartment of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, IranRenin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT2R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-6. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects.https://ijbms.mums.ac.ir/article_21929_06b00c767ebd88266c0ea5ec31641aef.pdfangiotensin iicancerkeloidscarskin diseasewound healing |
| spellingShingle | Keshvad Hedayatyanfard Azadeh Khalili Hosein Karim Soren Nooraei Ehsan Khosravi Nazgol Sadat Haddadi Ahmad Reza Dehpour Gholamreza Bayat Potential use of angiotensin receptor blockers in skin pathologies Iranian Journal of Basic Medical Sciences angiotensin ii cancer keloid scar skin disease wound healing |
| title | Potential use of angiotensin receptor blockers in skin pathologies |
| title_full | Potential use of angiotensin receptor blockers in skin pathologies |
| title_fullStr | Potential use of angiotensin receptor blockers in skin pathologies |
| title_full_unstemmed | Potential use of angiotensin receptor blockers in skin pathologies |
| title_short | Potential use of angiotensin receptor blockers in skin pathologies |
| title_sort | potential use of angiotensin receptor blockers in skin pathologies |
| topic | angiotensin ii cancer keloid scar skin disease wound healing |
| url | https://ijbms.mums.ac.ir/article_21929_06b00c767ebd88266c0ea5ec31641aef.pdf |
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